Publications by authors named "Mitsunori Shimmura"
Article Synopsis
- The study aimed to assess how effective serum prolactin (PRL) and lactate (LAC) levels are in diagnosing patients experiencing convulsions or transient loss of consciousness (TLOC) in the emergency room.
- Conducted at a single hospital, the research analyzed records from patients with either epileptic seizures, psychogenic non-epileptic seizures (PNES), or syncope, focusing on PRL and LAC measurements taken within three hours of their symptoms.
- Findings revealed that high serum PRL levels distinguished between epileptic seizures and PNES, but LAC levels were not significant for diagnosing syncope, suggesting PRL testing is valuable for specific diagnoses in convulsive cases while LAC is not a
Objectives: The objectives of this study were to determine how hemispheric laterality of seizure activity influences periictal heart rate variability (HRV) and investigate the ability of HRV parameters to discriminate right- and left-sided seizures.
Methods: Long-term video electroencephalogram-electrocardiogram recordings of 54 focal seizures in 25 patients with focal epilepsy were reviewed. Using linear mixed models, we examined the effect of seizure laterality on linear (standard deviation of R-R intervals [SDNN], root mean square of successive differences [RMSSD], low frequency [LF] and high frequency [HF] power of HRV, and LF/HF) and nonlinear (standard deviation [SD]1, SD2, and SD2/SD1 derived from Poincaré plots) periictal HRV parameters, the magnitude of heart rate (HR) changes, and the onset time of increased HR.
Article Synopsis
- * Researchers created a mouse model (Pten-cKO) with a deleted Pten gene to study the impact of the AKT-mTOR pathway, finding that these mice developed seizures and changes in brain structure after a certain age.
- * Treatment with the mTOR inhibitor rapamycin successfully prevented seizures and normalized brain changes in the mice, indicating that the mTOR pathway plays a significant role in regulating brain activity related to epilepsy.
Article Synopsis
- * She experienced symptoms like rapid breathing, high heart rate, high blood pressure, fever, and abnormal posturing, along with elevated catecholamine levels in her blood and urine.
- * Treatment with clonidine hydrochloride significantly improved her PSS symptoms, indicating it may be a viable therapeutic option for this condition.
Article Synopsis
- A 44-year-old man experienced a range of neurological symptoms, including hand tremors, difficulty concentrating, abnormal vision, and lower limb stiffness, leading to falls.
- Laboratory tests indicated significantly high serum creatine kinase levels and abnormal muscle discharges, prompting a diagnosis of Isaacs' syndrome based on a positive potassium channel antibody test.
- While initial treatment with an anticonvulsant did not improve his condition, high-dose intravenous methylprednisolone therapy led to significant clinical improvement, suggesting its effectiveness compared to other treatments for Isaacs' syndrome.