Publications by authors named "Mitsunori Noma"
Article Synopsis
- A study analyzed 402 young children with primary autoimmune neutropenia to compare clinical features between those with human neutrophil antigen 1 antibodies (HNA-1abs) and those without.
- Researchers used flow cytometry to identify HNA-1abs and categorized the children into positive, borderline, and negative groups based on their antibody levels.
- Children with HNA-1abs had significantly lower neutrophil counts, longer durations of neutropenia, and a higher risk of hospitalization compared to those without the antibodies.
Objectives: Optimal selection of pretransplant conditioning is crucially vital for improving survival and quality-of-life of patients who receive allogeneic hematopoietic cell transplantation (allo-HCT), particularly in those with high-risk diseases. In this study, we evaluated the efficacy and safety of recently-developed reduced-toxicity myeloablative regimen that combines fludarabine, intravenous busulfan, and melphalan (FBM).
Methods: We conducted a single-center retrospective analysis of 39 patients (23 with myeloid neoplasms and 16 with lymphoid neoplasms), with a median age of 50 (range, 17-68) years, who underwent their first allo-HCT using the FBM regimen.