Publications by authors named "Mitsunori Fukaya"
Article Synopsis
- Mushroom terpenoids are diverse fungal metabolites, with melleolides being key sesquiterpenoids that have a unique protoilludane structure.
- The study utilized a hot spot knock-in method to clarify the biosynthetic pathway of 1α-hydroxymelleolide, revealing the role of cytochrome P450 and short-chain dehydrogenase/reductase enzymes in the hydroxylation and stereochemical inversion processes.
- A notable aspect of this biosynthesis involves the flavoprotein Mld7, which facilitates a complex reaction that leads to melleolide and related compounds, with product distribution influenced by cell membrane interactions.
Biosynthetic machineries of anthraquinones and bisanthraquinones in Talaromyces islandicus.
Biosci Biotechnol Biochem
March 2022
Talaromyces islandicus is a unique fungus that produces more than 20 numbers of anthraquinones (AQs) and their dimeric natural products, bisanthraquinones (BQs). These compounds share a 9,10-anthracenedione core derived from emodin. The biosynthetic pathway of emodin has been firmly established, while that of other AQs and BQs is still unclear.
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