Sangyo Eiseigaku Zasshi
November 2006
Analysis by gas chromatograph after collection of personal samples is the most common method of evaluating individuals' exposures to organic solvents. This method provides us time-weighted averages (TWA) only, and does not measure fluctuating concentrations of organic solvents. A portable VOC monitor is widely used as a rapid screening instrument for volatile organic compounds (VOCs) in houses, schools, etc.
View Article and Find Full Text PDFThe metabolic fate of tributyltin and triphenyltin may contribute to the toxicity of these chemicals. We used human hepatic cytochrome P-450 (CYP) systems to confirm the specific CYP(s) involved in the in vitro metabolism of tributyltin and triphenyltin. There were no significant sex differences in the metabolic pattern of tributyltin or triphenyltin, indicating that the CYP(s) responsible for the metabolism of these chemicals in humans is/are not sex-specific form(s).
View Article and Find Full Text PDFEnviron Toxicol Pharmacol
September 2006
In the present study, dioctyltin chloride (DOTC: 100mg/kg, BW) was orally administered to immature (30-day-old) male rats, and the acute toxic effects were studied. Di- and monooctyltin (its metabolite) accumulations were mainly detected in the liver, and peaked 48h later. A similar pattern was also found in the kidney, but the levels were low or trace amounts.
View Article and Find Full Text PDFToxicol Appl Pharmacol
January 2006
Tributyltin is metabolized by cytochrome P-450 (CYP) system enzymes, and its metabolic fate may contribute to the toxicity of the chemical. In the present study, it is examined whether sex differences in the metabolism of tributyltin exist in rats. In addition, the in vivo and in vitro metabolism of tributyltin was investigated using rat hepatic CYP systems to confirm the principal CYP involved.
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