Vasohibin-1 as a Novel Prognostic Factor for Head and Neck Squamous Cell Carcinoma.

Aim: We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma.

Materials And Methods: Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically.

Does swallowing function recover in the long term in patients with surgically treated tongue carcinomas?

Purpose: The present study aimed to measure postsurgical swallowing function in patients 5 years after the surgical treatment of tongue carcinoma.

Patients And Methods: Using a retrospective cohort study design, the investigators enrolled postsurgical patients treated for tongue carcinomas in Hokkaido University Hospital. The primary outcome variable was oropharyngeal swallow efficiency (OPSE) determined by videofluoroscopic evaluation, and OPSE at follow-up was compared with that at discharge.

Pim-1 activation of cell motility induces the malignant phenotype of tongue carcinoma.

Pim-1 is a serine/threonine kinase as well as a proto-oncogene that induces T-cell lymphoma. Pim-1 induces cell cycle progression in cooperation with c-Myc and acts as an inhibitor of apoptotic cell death, actions that are involved in blood cell oncogenesis. However, little is known regarding the role of Pim-1 in oral carcinogenesis.