Publications by authors named "Mitsuko Hosoi"
Article Synopsis
- Endoplasmic reticulum-mitochondrial contact sites (ERMCS) are crucial for mitochondrial function, calcium signaling, and autophagy, and their disruption is associated with neurodegenerative diseases like Alzheimer's and Parkinson's.
- Researchers examined ERMCS in dopaminergic neurons derived from a patient with a genetic mutation linked to Parkinson's, finding a significant reduction in ERMCS compared to control neurons.
- The study suggests that this decrease in ERMCS leads to impaired calcium signaling between the endoplasmic reticulum and mitochondria, contributing to the degeneration of dopaminergic neurons in patients with mutations.
Recently, we reported the presence of distinct cell clusters named acinar-like cell clusters touching Langerhans islets with thin interstitial surrounding (ATLANTIS) in human pancreas. A morphological study in humans demonstrated that ATLANTIS and islet cell clusters are found together in the microenvironment enclosed by a common basement membrane, and ATLANTIS releases vesicles containing Regenerating gene protein (REG Iα) to islet cell clusters. We examined 1) the presence or absence of ATLANTIS in homozygous Reg I (mouse homologue of human REG Iα) deficient (Reg I) and wild-type mice, and 2) the possible role of ATLANTIS in the regeneration of beta cell clusters after encephalomyocarditis (EMC) virus (D-variant) infection in Reg I and wild-type mice.
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