Publications by authors named "Mitsuki Umino"
Article Synopsis
- Carnosine, anserine, and homocarnosine are important dipeptides found in muscles and the brain, with carnosine and anserine extensively studied for their effects on muscle function and exercise performance.
- Research on homocarnosine, primarily in the brain, is limited, leading to an investigation of its role in behaviors using carnosine synthase-1-deficient mice.
- The study observed that older Carns1 mice displayed hyperactivity and signs of depression along with altered hormone levels, while homocarnosine deficiency had subtle effects on GABA levels in the brain, suggesting that these dipeptides may play a significant role in behavior and potential neurological disorders.
We evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.
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