Publications by authors named "Mitsui H"
Activities on sandy soil are known to contribute to improved leg strength and balance. Lifesavers (LSs) have shown that sandy soil activity promotes intrinsic foot muscle development and improves balance. LS improves leg strength and balance through activities on sandy soil.
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- Generalized pustular psoriasis (GPP) is a serious skin condition characterized by recurrent, sterile pustules, primarily driven by the cytokine interleukin (IL)-36.
- A patient with a specific genetic variant did not respond adequately to treatment with spesolimab, which blocks IL-36 receptor signaling, as it helped reduce existing symptoms but failed to prevent new flare-ups.
- After noticing the resistance to spesolimab, bimekizumab, an antibody targeting IL-17A/IL-17F, was introduced and successfully resolved the patient's pustules and erythema, prompting a discussion on the underlying mechanisms of the resistance to spesolimab.
Deep burn injuries necessitate effective debridement to promote healing and reduce complications. Traditional surgical debridement is the standard of care; however, it can lead to significant tissue loss, excessive bleeding and delayed healing. Bromelain-based enzymatic debridement offers a potential less invasive alternative that aims to selectively remove necrotic tissue while preserving viable ones.
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- Atopic dermatitis (AD) is a chronic skin disease characterized by intense itching, and new treatments like dupilumab have been developed but predicting the right treatment for each patient is challenging.
- A study involving 110 AD patients aimed to identify factors and biomarkers that could indicate how well patients might respond to dupilumab, using various scales for assessment.
- Findings showed that higher baseline serum LDH levels and certain comorbidities, like food allergies, were linked to poorer treatment outcomes, suggesting these could help guide treatment decisions for AD patients.
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- Balance is crucial for elite lifesavers, and the study examines how dynamic balance relates to physical traits and functions.
- Researchers analyzed factors such as foot muscle area, ankle strength, toe grip strength, and foot sensation in 15 adult lifesavers (mostly male).
- Findings suggest that strong toe grip and ankle strength are key for maintaining balance on sand, and while sand training enhances these abilities, it might also reduce foot sensation if the intensity is too high—further research is needed.
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- Obesity not only increases the risk of various diseases but also causes skin issues like dryness and itching, highlighting the need for effective treatments, as previously unexplored in research.
- This study tested the effects of linseed oil, rich in omega-3 fatty acids, on the skin barrier in obese mice over eight weeks, measuring skin hydration and inflammatory markers after UV exposure.
- Results showed that linseed oil improved skin barrier function by reducing water loss, inflammation, and skin damage, suggesting it could be a beneficial dietary addition for managing skin health in obesity.
Purpose: We aimed to perform a systematic review and meta-analysis addressing the efficacy of levothyroxine therapy in pregnant women with subclinical hypothyroidism considering most recent evidence and subgroups of interest for clinical practice.
Methods: PubMed, Embase, and Cochrane Central were searched from inception for randomized controlled trials (RCTs) comparing levothyroxine with placebo or no intervention in pregnant women with subclinical hypothyroidism. We used a random-effects model and conducted subgroup analyses based on thyroid peroxidase antibody status, thyroid stimulating hormone levels, fertility treatment, and recurrent miscarriage.
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- A 43-year-old woman had robot-assisted thoracic surgery for an anterior mediastinal tumor, using a subxiphoid approach.
- During the procedure, significant blood pressure drop occurred shortly after carbon dioxide (CO2) was introduced for insufflation.
- The issue was identified as a left-sided pericardial injury causing cardiac tamponade, which was resolved by making an incision in the right pericardium, leading to improved blood pressure.
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- - Vitiligo, an autoimmune skin disease causing loss of pigment, was studied in adult Japanese patients to understand the impact of dietary habits on its development, focusing on factors like BMI and nutrient intake compared to healthy controls.
- - The study found that vitiligo patients had a higher BMI and lower consumption of certain nutrients like manganese and vitamin D, with significant correlations between male sex, age, dietary intake, and the severity of vitiligo symptoms.
- - Results suggest managing obesity may help prevent or treat vitiligo, as specific dietary habits were linked to higher disease severity in differing body areas.
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- * Diagnostic imaging and histological analysis indicated that the mass was linked to gangrene and torsion related to polydactyly.
- * This case is unique as it involves radial polydactyly with prenatal torsion, which is rare, particularly since such occurrences have primarily been noted in ulnar polydactyly.
The ability of biomarkers to assess the severity of atopic dermatitis.
J Allergy Clin Immunol Glob
February 2024
Article Synopsis
- * Researchers evaluated objective (Eczema Area and Severity Index - EASI) and subjective (Patient-Oriented Eczema Measure - POEM and pruritis-NRS) symptoms of AD and found strong associations between various biomarkers and these assessments.
- * Key findings suggest that CCL26/eotaxin-3 and SCCA2 are the most effective biomarkers for measuring AD severity via EASI, while lactate dehydrogenase is best for assessing symptoms on POEM and pruritis-NRS. *
NO is an important greenhouse gas influencing global warming, and agricultural land is the predominant (anthropogenic) source of NO emissions. Here, we report the high NO-reducing activity of Bradyrhizobium ottawaense, suggesting the potential for efficiently mitigating NO emission from agricultural lands. Among the 15 B.
View Article and Find Full Text PDFRisk factors of severe coronavirus disease 2019 (COVID-19) have been previously reported; however, histological risk factors have not been defined thus far. The aim of this study was to clarify subclinical hidden interstitial lung disease (ILD) as a risk factor of severe pneumonia associated with COVID-19. We carefully examined autopsied lungs and chest computed tomography scanning (CT) images from patients with COVID-19 for interstitial lesions and then analyzed their relationship with disease severity.
View Article and Find Full Text PDFTricho-rhino-phalangeal syndrome type I (TRPS1), caused by pathogenic variants in the transcriptional repressor GATA-binding 1 gene (TRPS1), is characterized by ectodermal and skeletal anomalies including short stature and sparse scalp hair during infancy. TRPS1 encodes a zinc finger protein transcription factor that contributes to bone homeostasis by regulating perichondral mineralization, chondrocyte proliferation, and apoptosis. Here, a male infant aged 14 months presented with sparse scalp hair, deformed nails, fused teeth, and postnatal growth retardation without neurodevelopmental disorder.
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- Bullous pemphigoid (BP) is an autoimmune skin disease influenced by dietary habits, prompting a study comparing dietary intake between Japanese BP patients and healthy individuals.
- The study found BP patients consumed less vitamin A (retinol) and beverages, and more spices; their disease severity correlated with certain nutrient intakes.
- The researchers suggest that vitamin A supplementation may help prevent or treat BP symptoms due to its notable dietary associations with the disease severity.
Melanoma accounts for the majority of skin cancer-related mortality, highlighting the need to better understand melanoma initiation and progression. In-depth molecular analysis of neoplastic melanocytes in whole tissue biopsies may be diluted by inflammatory infiltration, which may obscure gene signatures specific to neoplastic cells. Thus, a method is needed to precisely uncover molecular changes specific to tumor cells from a limited sample of primary melanomas.
View Article and Find Full Text PDFThe natural course of Stanford type A acute aortic dissection (AAAD) has a poor prognosis. Early diagnosis is crucial, but in clinical practice some patients do not have typical symptoms, leading to a delay in diagnosis. We encountered a patient who complained only of shoulder pain and moderate respiratory distress.
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