Publications by authors named "Mitsuhiro Chousa"
Treatment with granulocyte colony-stimulating factor (G-CSF) reportedly mitigates postinfarction cardiac remodeling and dysfunction. We herein examined the effects of G-CSF knockout (G-CSF-KO) on the postinfarction remodeling process in the hearts of mice. Unexpectedly, the acute infarct size 24 hours after ligation was similar in the two groups.
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- Antiendothelial cell antibodies (AECAs) have been found in both autoimmune and inflammatory diseases, and this study specifically focused on AECAs targeting human brain microvascular endothelial cells (HBMEC).
- The researchers detected 250 antigen spots reacting with AECAs in serum samples from 30 healthy subjects, identifying 10 common spots present in over 25% of samples.
- By using mass spectrometry, they identified 7 key proteins—such as glucose-regulated protein and annexin A2—that are likely the main targets for natural AECAs in these individuals.
The pathogenesis of cerebral small vessel disease (CSVD) in the elderly is poorly understood. Endothelial cell activation and dysfunction may play a causal role in the pathogenesis of CSVD. It was reported that anti-endothelial cell antibodies (AECAs) are associated with endothelial cell dysfunction and inflammation.
View Article and Find Full Text PDFWe report the death of a 61-year-old Japanese man massively transfused during and after emergency aortic surgery. Postoperative on day 8, he died after cardiac arrest associated with hyperkalemia. Indirect antiglobulin testing demonstrated both anti-Di(b) and anti-E antibodies pre-transfusion, and elevation of their titers as the delayed hemolytic transfusion reaction evolved.
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- Recent studies indicate microvascular issues are linked to Alzheimer’s disease progression.
- The study aimed to find antibodies against brain microvessels specifically in Alzheimer's patients and their relation to cognitive decline.
- The anti-Tom40 antibody was more common in Alzheimer’s patients, and those positive for it scored lower on cognitive tests compared to those who were negative.
Background: To expand the criteria of immune thrombocytopenic purpura (ITP), which is a diagnosis of exclusion, we analyzed proteins separated by 1-dimensional gel electrophoresis of the retained fraction in a Con A-Sepharose column from ITP patients' sera.
Methods: Serum samples were from 19 adult patients with chronic ITP, 9 patients with thrombocytopenia of decreased production, and 20 healthy controls. Samples were applied to a Con A-Sepharose column, and the retained fraction was subjected to 10% SDS-PAGE.