Synthesis of Hollowed Polyoxometalate with a Flipped VO Unit by the Elimination of a Centered Organic Molecule.

Mechanistic understanding of the formation of clusters plays a role in designing the structure-dependent properties. Based on the fact that anions act as templates to form spherical polyoxovanadates, various structures were reported by changing anions in the synthetic solution. In this work, another factor in the formation of spherical polyoxometalates was demonstrated.

Successful management of immunotherapy-resistant respiratory failure in anti-mitochondrial M2 antibody-positive myositis by modified lung volume recruitment therapy: A case report.

Rationale: Anti-mitochondrial antibodies (AMA) M2-positive myositis can lead to severe respiratory failure. Traditional immunotherapies sometimes fail to address respiratory failure. Herein, this CARE-compliant case report described a patient with AMA-M2-positive myositis who recovered from ventilation with tracheostomy owing to immunotherapy-resistant respiratory failure to spontaneous breathing after modified lung volume recruitment (mLVR) therapy.

Controlling the symmetry of hexamonodentate 3d-transition metal complexes through symmetry propagation from high-symmetry Ti-Mo and Zr-Mo clusters hydrogen-bonding interactions.

The symmetry of one of the simplest hexamonodentate complexes, [M(HO)] (M = Fe, Co, Ni, and Zn), was controlled by tuning interactions in the second coordination sphere. Highly symmetric Ti-Mo or Zr-Mo cluster cations acted as symmetry templates, imposing a crystallographic trigonal coordination geometry in the hexamonodentate complexes through intermolecular hydrogen-bonding interactions. Magnetic measurements revealed that the ideal trigonal symmetry results in weak spin-orbit coupling for high-spin Fe complexes, despite the T-term ground state in the octahedral geometry.

Reactivity control of nitrate-incorporating octadecavanadates by changing the oxidation state and metal substitution.

Clarification and control of the active sites at the atomic/molecular level are important to develop nanocatalysts. The catalytic performance of two oxidation states of nitrate-incorporating octadecavanadates, [VO(NO)] (V18) and [VO(NO)] (V18ox), and a copper-substituted one, [CuVO(NO)] (Cu2V16), in selective oxidation was investigated. Both V18 and V18ox possessed the same double-helical structures and one of two tetravalent vanadium sites of V18 was oxidized in V18ox.

Design and fabrication of a coupled high-Q photonic nanocavity system with large coupling coefficients.

In a previous work, we demonstrated a coupled cavity system where photons in one storage cavity can be transferred to another storage cavity at an arbitrary time by applying a voltage pulse to a third cavity placed in a p-i-n junction. In this work, we demonstrate methods to improve the transfer efficiency and photon lifetimes of such a coupled system. Firstly, we designed a photonic-crystal structure that achieves a large coupling coefficient without reducing the radiation quality factor compared to the previously proposed structure: The photonic-crystal design was changed to a more symmetric configuration to suppress radiation losses and then optimized using an automatic structure tuning method based on the Covariance Matrix Adaptive Evolutional Strategy (CMAES).

Reactivity of Organoiridium Tungsten Oxide Clusters with Transition Metal Aquo Cations.

Organometallic-polyoxometalate (POM) complexes form a unique class of molecular organometallic oxides characterized by the dynamic behavior of the organometallic cations. Herein, we investigated the reactivity of Cp*Ir-octatungstate clusters (where Cp* represents pentamethylcyclopentadienyl, CMe) with Werner-type transition-metal aquo cations. The addition of Ag, Co, Ni, and M (M = Cr, Fe, or In) cations to the aqueous solution of Cp*Ir-octatungstate clusters resulted in the formation of [{Ag(OH)}{Cp*Ir(OH)}{Cp*IrWO(OH)}(WO)] (), CoKNa[{-Co(OH)}{Cp*IrWO(OH)}(WO){-Co(OH)}] (), NiKNa[{Ni(OH)}{Cp*IrWO(OH)}(WO){-Ni(OH)}] (), and [{M(OH)}{Cp*IrWO(OH)}{-M(OH)}](NO) (M = Cr, ; Fe, ; or In, ), respectively.

Silicon nanocavity with a quality factor of 6.7 million fabricated by a CMOS-compatible process.

Here, we report on the increase of the quality-factors of photonic crystal nanocavities fabricated by a CMOS-compatible process. We fabricated nanocavities with the same cavity design but used either a binary photomask or a phase-shift photomask in the photolithography step to assess the impact of the photomask-type on the fabrication accuracy of the air holes. We characterized 62 cavities using time-resolved measurements and the best cavity had a quality-factor of 6.

Factors Associated with the Prevalence and Severity of Menstrual-Related Symptoms: A Systematic Review and Meta-Analysis.

This study aimed to identify factors associated with the prevalence and severity of menstrual-related symptoms. The protocol was registered in PROSPERO (CRD42021208432). We conducted literature searches of PubMed and Ichushi-Web and used the Jonna Briggs Institute critical appraisal checklist to assess the quality.

Selective Formation of Intramolecular Hydrogen-Bonding Palladium(II) Complexes with Nucleosides Using Unsymmetrical Tridentate Ligands.

Three palladium(II) complexes with amino-amidato-phenolato-type tridentate ligands were synthesized and characterized by H NMR spectroscopy and X-ray crystallography. The strategic arrangement of a hydrogen-bond donor and acceptor adjacent to the substitution site of the Pd complex allowed the selective coordination of nucleosides. Among two pyrimidine-nucleosides, cytidine and 5-methyluridine, cytidine was successfully coordinated to the Pd complex while 5-methyluridne was not.

Structures of Dimer-of-Dimers Type Defect Cubane Tetranuclear Copper(II) Complexes with Novel Dinucleating Ligands.

Only a limited number of multinucleating ligands can stably maintain multinuclear metal structures in aqueous solutions. In this study, a water-soluble dinucleating ligand, 2,6-bis{[-(carboxylatomethyl)--methyl-amino]methyl}-4-methylphenolate ((-cmp)), was prepared and its copper(II) complexes were structurally characterized. Using the single-crystal X-ray diffraction method, their dimer-of-dimers type defect cubane tetranuclear copper(II) structures were characterized for [Cu(-cmp)Cl(HO)] and [Cu(-cmp)(CHO)(CHOH)].

Automatic Classification of Adult Males With and Without Autism Spectrum Disorder by Non-contact Measurement of Autonomic Nervous System Activation.

People with autism spectrum disorder (ASD) exhibit atypicality in various domains of behavior. Previous psychophysiological studies have revealed an atypical pattern of autonomic nervous system (ANS) activation induced by psychosocial stimulation. Thus, it might be feasible to develop a novel assessment tool to evaluate the risk of ASD by measuring ANS activation in response to emotional stimulation.

A reduced physiological F-fluorodeoxyglucose uptake in the brain and liver caused by malignant lymphoma being deprived of the tracer.

Purpose : To investigate whether or not the physiological brain and liver FDG uptake are decreased in patients with highly accelerated glycolysis lesions. Methods : We retrospectively analyzed 51 patients with malignant lymphoma. We compared the FDG uptake in the brain and liver of the patients with that in a control group.

Influence of Quaternary environmental changes on mole populations inferred from mitochondrial sequences and evolutionary rate estimation.

Quaternary environmental changes fundamentally influenced the genetic diversity of temperate-zone terrestrial animals, including those in the Japanese Archipelago. The genetic diversity of present-day populations is taxon- and region-specific, but its determinants are poorly understood. Here, we analyzed cytochrome b gene (Cytb) sequences (1140 bp) of mitochondrial DNA (mtDNA) to elucidate the factors determining the genetic variation in three species of large moles: Mogera imaizumii and Mogera wogura, which occur in central and southern mainland Japan (Honshu, Shikoku, and Kyushu), and Mogera robusta, which occurs on the nearby Asian continent.

Structure Controlling Factors of Oxido-Bridged Dinuclear Iron(III) Complexes.

Oxido bridges commonly form between iron(III) ions, but their bond angles and symmetry vary with the circumstances. A large number of oxido-bridged dinuclear iron(III) complexes have been structurally characterized. Some of them belong to the point group, possessing bent Fe-O-Fe bonds, while some others belong to the symmetry, possessing the linear Fe-O-Fe bonds.

Suppression of Lipid Accumulation in 3T3-L1 Adipocytes by α-Tocopheryl Succinate.

Obesity is a pathological state related to various lifestyle-related diseases, such as diabetes and dyslipidemia, that may be prevented through the development of anti-obesity treatments. Lipid accumulation in cells could be affected by vitamin E ester α-tocopheryl succinate (TS), which has various biological activities, such as anti-cancer effect, via activation of cell signaling pathways, although the antioxidative activity of TS is lost due to esterification of the phenolic OH group. In this study, we found for the first time that TS significantly suppressed lipid accumulation in mouse 3T3-L1 adipocytes.

Zero-field slow relaxation of magnetization in cobalt(ii) single-ion magnets: suppression of quantum tunneling of magnetization by tailoring the intermolecular magnetic coupling.

The correlation between magnetic relaxation dynamics and the alignment of single-ion magnets (SIMs) in a crystal was investigated using four analogous cobalt(ii) complexes with unique hydrogen-bond networks. The hydrogen-bonding interactions in the crystals resulted in a relatively short intermolecular Co⋯Co distance, which led to non-zero intermolecular magnetic coupling. All the complexes with a Co⋯Co distance shorter than 6.

Anti-TNF-α Therapy for Refractory Uveitis Associated with Behçet's Syndrome and Sarcoidosis: A Single Center Study of 131 Patients.

Purpose: The efficacy of infliximab (IFX) and adalimumab (ADA) for treating Behçet's syndrome (BS) and sarcoidosis has not been compared adequately.

Methods: We reviewed the medical records of patients with uveitis diagnosed at Tokyo Medical University Hospital and compared the efficacy of IFX and ADA for BS and the efficacy of ADA for sarcoidosis and BS.

Results: 68 patients in IFX group and 63 patients in ADA group were analyzed.

Detailed magnetic analysis and successful deep-neural-network-based conformational prediction for [VO(dmso)][BPh].

Pentakis(dimethylsulfoxide-κ)oxidovanadium(iv) bis(tetraphenylborate), [VO(dmso)][BPh] (dmso: dimethylsulfoxide), was synthesized, and its pseudo- VO coordination geometry was revealed by a single-crystal X-ray method. A novel equation set was obtained for magnetic susceptibility and magnetization of the d complexes, considering the axial distortion and the spin-orbit coupling for the D free-ion term. The equation set enabled magnetic simulation for significantly symmetry-lowered d complexes to obtain the anisotropic -values and also the excitation energies.

Terahertz tag identifiable through shielding materials using machine learning.

In recent years, there has been great interest in chipless radio-frequency identification (RFID) devices that work in the terahertz (THz) frequency range. Despite advances in RFID technology, its practical use in the THz range has yet to be realized, due to cost and detection accuracy issues associated with shielding materials. In this study, we propose two types of low-cost THz-tags; one is based on the thickness variation of coated polyethylene and the other on the fingerprint spectra of reagents.

Changes in Etiology of Uveitis in a Single Center in Japan.

: We investigated the changes in etiology of uveitis at the Uveitis Clinic of Tokyo Medical University Hospital in recent years.: Medical records of patients with uveitis diagnosed between 2011 and 2017 (Group A) and between 2001 and 2007 (Group B) were reviewed.: 1,587 patients in group A and 1,507 patients in group B were analyzed.

Unusual Magneto-Structural Features of the Halo-Substituted Materials [Fe (5-X-salMeen) ]Y: a Cooperative [HS-HS]↔[HS-LS] Spin Transition.

X-ray structures of the halo-substituted complexes [Fe (5-X-salMeen) ]ClO (X=F, Cl, Br, I) [salMeen=N-methyl-N-(2-aminoethyl)salicylaldiminate]at RT have revealed the presence of two discrete HS complex cations in the crystallographic asymmetric unit with two perchlorate counter ions linking them by N-H ⋅⋅⋅O interactions. At 90 K, the two complex cations are distinctly HS and LS, a rare crystallographic observation of this coexistence in the Fe -salRen (R=alkyl) spin-crossover (SCO) system. At both temperatures, crystal packing shows dimerization through C-H ⋅⋅⋅O interactions, a key feature for SCO cooperativity.

Biological Functions of α-Tocopheryl Succinate.

α-Tocopheryl succinate (TS) is a succinic acid ester of a well-known natural antioxidant α-tocopherol (α-T). Physicochemical characteristics of TS are entirely different from the original compound α-T. TS becomes vesicles via forming a lamella structure.

Hydrogen-bonding interactions and magnetic relaxation dynamics in tetracoordinated cobalt(ii) single-ion magnets.

Three tetracoordinated cobalt(ii) complexes with a series of unsymmetrical bidentate ligands were synthesized and crystallographically characterized. Although their static magnetic properties are similar, their dynamic magnetic properties differ drastically depending indirectly on intermolecular hydrogen-bonding interactions.

Risk of female athlete triad development in Japanese collegiate athletes is related to sport type and competitive level.

Introduction: Menstrual dysfunction, musculoskeletal injury, and poor nutrition combine to form the female athlete triad (FAT), which results in serious health consequences for affected athletes. To this point, the risk factors of this phenomenon have not been fully explored in Japanese female college athletes. Additionally, the effect of competitive level on FAT risk factors has also not been reported.

Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized click reactions.

The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional moieties to permeabilize bacterial cell membranes.