The waist circumference-adjusted associations between hyperuricemia and other lifestyle-related diseases.

Background: Few studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex.

Methods: This cross-sectional study included 33,498 Japanese individuals, and was conducted at the Center for Preventive Medicine, NTT Kanto Medical Center, Tokyo, from May 2006 to March 2015. Hyperuricemia was defined as a uric acid level of >7 mg/dl in men; >6 mg/dl in women.

The Relationships between Metabolic Disorders (Hypertension, Dyslipidemia, and Impaired Glucose Tolerance) and Computed Tomography-Based Indices of Hepatic Steatosis or Visceral Fat Accumulation in Middle-Aged Japanese Men.

Background: Most studies on the relationships between metabolic disorders (hypertension, dyslipidemia, and impaired glucose tolerance) and hepatic steatosis (HS) or visceral fat accumulation (VFA) have been cross-sectional, and thus, these relationships remain unclear. We conducted a retrospective cohort study to clarify the relationships between components of metabolic disorders and HS/VFA.

Methods: The participants were 615 middle-aged men who were free from serious liver disorders, diabetes, and HS/VFA and underwent multiple general health check-ups at our institution between 2009 and 2013.

Utility of 75-g oral glucose tolerance test results and hemoglobin a1c values for predicting the incidence of diabetes mellitus among middle-aged Japanese men -a large-scale retrospective cohort study performed at a single hospital.

Objective: The aim of this study was to investigate the associations between the incidence of diabetes and the accumulation of markers of impaired glucose metabolism; i.e., pre-diabetes.

Associations between healthy lifestyle behaviors and proteinuria and the estimated glomerular filtration rate (eGFR).

Aim: The aim was to investigate the respective associations between lifestyle and proteinuria and the estimated glomerular filtration rate (eGFR).

Methods: The lifestyle habits of 25,493 middle-aged participants were investigated in a cross-sectional study to find habits that are associated with a low eGFR (<60 mL/min/1.73 m(2)) and/or the presence of proteinuria.

A cross-sectional study on the risk factors for erosive esophagitis in young adults.

Objective: To investigate the impact of metabolic and lifestyle factors on erosive esophagitis in young adults.

Methods: A total of 5,069 people under the age of 40 years old were enrolled in a medical survey at our institute. People with a previous history of upper gastrointestinal tract surgery were excluded, as were individuals taking medication for reflux symptoms, peptic ulcers, or malignancies.

Modest alcohol consumption has an inverse association with liver fat content.

Background/aims: Modest alcohol consumption has been suggested to be protective against alanine amino-transferase activities and ultrasonography-defined fat-ty liver. We aimed to explore the association between alcohol consumption and liver fat content as quantitative-ly determined by computed tomography (CT).

Methodology: One-thousand two-hundred thirty-one Japanese males, aged over 40 years, voluntarily participated ina health check-up program including CT screening in 2009-2010.

Alcohol consumption is inversely correlated with insulin resistance, independent of metabolic syndrome factors and fatty liver diseases.

Background And Aim: The role of alcohol consumption in insulin resistance remains unclear. The aim of this study was to examine the association between alcohol consumption and insulin resistance in a large asymptomatic population.

Methods: A total of 2463 asymptomatic Japanese men aged 28 years or above undergoing a comprehensive health checkup including an oral glucose tolerance test between May 2007 and April 2010 were recruited.

Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males.

Background: The impact of obesity on gastroesophageal reflux disease remains controversial. We undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) as covariates.

Methods: Japanese males who visited our institute for a comprehensive medical survey between 2007 and 2010 were enrolled.

Risk factors for serum alanine aminotransferase elevation: A cross-sectional study of healthy adult males in Tokyo, Japan.

Background: Liver-protective effects of light-to-moderate alcohol consumption have been suggested.

Aims: To determine predictors of ALT elevation in asymptomatic subjects with and without ultrasonographical evidence of fatty liver.

Methods: Cross-sectional survey of 9703 healthy males.

Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population.

Background: Helicobacter pylori infection has been shown to contribute to atherosclerosis and cardiovascular diseases. Insulin resistance is the pathophysiologic background of the clinical features of atherosclerosis and cardiovascular diseases. We examined the association between H.

Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population.

Objectives: The effect of alcohol consumption on the liver is controversial. Recent reports have suggested that moderate alcohol consumption decreases the prevalence of elevated alanine aminotransferase levels. The role of alcohol consumption in the development of fatty liver (FL), however, has not been studied definitively.

Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population.

Background: Metabolic syndrome comprises a cluster of metabolic abnormalities leading to insulin resistance and atherosclerosis, and Helicobacter pylori is thought to be a contributing factor.

Aim: We examined the association between H. pylori infection and metabolic syndrome in a large Japanese population.