Imaging angiogenesis in atherosclerosis in large arteries with Ga-NODAGA-RGD PET/CT: relationship with clinical atherosclerotic cardiovascular disease.

Background: Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis and inflammation and represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis. The aim of this study was to assess the clinical correlates of arterial wall accumulation of Ga-NODAGA-RGD, a specific αβ integrin ligand for PET.

Materials And Methods: The data of 44 patients who underwent Ga-NODAGA-RGD PET/CT scans were retrospectively analyzed.

Head and neck tumors angiogenesis imaging with Ga-NODAGA-RGD in comparison to F-FDG PET/CT: a pilot study.

Background: Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of Ga-NODAGA-RGD PET/CT for imaging αβ integrins involved in tumor angiogenesis to F-FDG PET/CT in patients with HNSCC.

Material And Methods: Ten patients (aged 58.

First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist Ga-NODAGA-MJ9.

Background: Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection.

First in-human radiation dosimetry of Ga-NODAGA-RGDyK.

Background: Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques.

F-FDG PET/CT predicts survival after Y transarterial radioembolization in unresectable hepatocellular carcinoma.

Purpose: To compare the value of pretreatment functional and morphological imaging parameters for predicting survival in patients undergoing transarterial radioembolization using yttrium-90 (Y-TARE) for unresectable hepatocellular carcinoma (uHCC).

Methods: We analysed data from 48 patients in our prospective database undergoing Y-TARE treatment for uHCC (31 resin, 17 glass). All patients underwent F-FDG PET/CT and morphological imaging (CT and MRI scans) as part of a pretherapeutic work-up.

Resin Versus Glass Microspheres for Y Transarterial Radioembolization: Comparing Survival in Unresectable Hepatocellular Carcinoma Using Pretreatment Partition Model Dosimetry.

The aim of this study was to compare survival of patients treated for unresectable hepatocellular carcinoma (uHCC) with Y transarterial radioembolization (TARE) using pretreatment partition model dosimetry (PMD). We performed a retrospective analysis of prospectively collected data on 77 patients consecutively treated (mean age ± SD, 66.4 ± 12.

[Cardiac sarcoidosis: seven keypoints to remind in order to avoid misdiagnosis].

Early diagnosis of cardiac sarcoidosis remains difficult in the absence of specific symptoms. The evolution and prognosis of the disease are strongly correlated to an early and appropriate treatment. The multi-modality assessment based on cardiac MRI and positron emission tomography associated with computed tomography (PET/CT) has significantly improved the detection of cardiac sarcoidosis over the last two decades.

Pulmonary Hypertension and Indicators of Right Ventricular Function.

Pulmonary hypertension (PH) is a rare disease, whose underlying mechanisms are not fully understood. It is characterized by pulmonary arterial vasoconstriction and vessels wall thickening, mainly intimal and medial layers. Several molecular pathways have been studied, but their respective roles remain unknown.

Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents.

Background: The association between chronic lymphocytic thyroiditis (CLT) and thyroid cancer is an interesting topic. The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without CLT.

Methods: The medical records of children and adolescents (≤21 years old) were reviewed.

Papillary thyroid carcinomas in patients under 21 years of age: clinical and histologic characteristics of tumors ≤10 mm.

Objective: To compare clinical and histologic characteristics of papillary thyroid carcinomas (PTCs) ≤10 mm in patients ≤21 years old with larger ones and with microcarcinomas in adults.

Study Design: Retrospective study of patients with PTC diagnosed between 1983 and 2012. Medical records were reviewed and information about age, sex, tumor size, intra/extrathyroid extension, lymph node, and distant metastases were collected.

The increase in thyroid cancer incidence is not only due to papillary microcarcinomas: a 40-year study in 1 778 patients.

Aim: Thyroid cancer incidence has been increased over the last decades. The aims of the present study were: (a) to identify a changing trend in thyroid cancer in Northern Greece, (b) to examine patients' and tumoral characteristics and (c) to investigate the increase of papillary microcarcinomas and that of invasive or larger cancers.

Patients And Methods: We retrospectively analyzed the records of 1 778 patients who were diagnosed with thyroid cancer between January 1971 and December 2010.

Parathyroid involvement in thyroid cancer: an unforeseen event.

Background: Parathyroid metastatic disease from thyroid cancer has not been studied extensively, mainly due to the need for parathyroid preservation during thyroid surgery.

Methods: We reviewed files from 1,770 patients with thyroid cancer followed up in our department and 10 patients with parathyroid metastases (0.5%) were identified.

99mTc pertechnetate thyroid scan leads to serendipitous detection of metastatic thyroid cancer.

99mTc pertechnetate is considered insensitive in detecting thyroid carcinoma metastases. We report the case of a 71-year-old male patient, in whom metastasis of an unknown thyroid cancer was diagnosed incidentally on a routine 99mTc pertechnetate scan, performed for the assessment of nodular thyroid disease. Marked tracer accumulation was unexpectedly noted on the left frontal region, where a palpable, painless, soft tissue mass was present.