The Preparation, Biodistribution, and Dosimetry of Encapsulated Radio-Scandium in a Dendrimer for Radio-nano-pharmaceutical Application.

This study aimed to investigate the synthesis, characterization, and biodistribution of scandium nanoparticles encapsulated within poly (amidoamine) (PAMAM) dendrimers, as well as to estimate the human absorbed dose. It also aimed to examine, in particular, the amine-terminated PAMAM dendrimers in generation 5. Irradiation of the compound in the nuclear reactor resulted in the formation of Sc-radioactive complex nanoparticles.

Development and Validation of a New Domestic Software for Dose Assessment during Normal and Accident Conditions in Nuclear Power Plants (NPPS).

In this research, a comprehensive code called KIANA is developed based on the Gaussian plume model to simulate and predict the radiological consequences received through all the possible, reasonable, probable, and standard exposure pathways for NPPs and chemical facilities. To validate the KIANA code, a case study is modeled for Bushehr Nuclear Power Plant Unit One (BNPP-1), and the KIANA code results are compared with the results of the Final Safety Analysis Report (FSAR-2017) data of BNPP-1. To assess the performance of the KIANA code, the total dose due to the airborne pathway in accident conditions including small break LOCA (SBLOCA), large break LOCA (LBLOCA), and equivalent exposure dose for the thyroid gland of a group of infants and children age 1 to 8 y at BNPP-1, are investigated.

THE VALIDATION OF COMPREHENSIVE SOFTWARE FOR THE ASSESSMENT OF RADIOLOGICAL IMPACTS ON HUMANS THROUGH BENCHMARK ANALYSIS WITH RADIOLOGICAL CODES.

In this paper, a novel domestic code called KIANA was developed for the assessment of radiological impacts on the population in normal and accident conditions including design basis accident (DBA) and beyond DBA (BDBA) for the nuclear power plants. The validation process of the KIANA code was performed using the results of the DOZA_M radiological code, whose results are presented in the Final Safety Analysis Report (FSAR) of the Bushehr Nuclear Power Plant Unit One (BNPP-1). The calculations of KIANA are performed based on the Gaussian diffusion model.

Dosimetry of Ytterbium-poly (amidoamine) Therapy for Humans' Organs.

Purpose: This investigation focuses on biodistribution of irradiated dendrimer encapsulated ytterbium-175 (Yb) and to estimate the absorbed dose from intravenous injection of PAMAM encapsulated Yb to human organs.

Methods: A dendrimer compound containing an average of 55 Yb ions per dendrimer was prepared and irradiated with neutrons for 2h at 3×10 n.cm-s- neutron flux.

Technetium-99m Tricarbonyl Labeled a Broad-spectrum Quinolone as a Specific Imaging Agent in Infection Diseases.

Nuclear medicine imaging has been used to localize infection sites, and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [Tc (CO) (HO)] core in order to evaluate its feasibility as an infection imaging agent for use. The stability of radioconjugate was checked in human serum at 37 °C and biodistribution was studied in mice.

Presenting and simulating an innovative model of liver phantom and applying two methods for dosimetry of it in neutron radiation therapy.

Aim: A new model of liver phantom is defined, then this model is simulated by MCNPX code for dosimetry in neutron radiation therapy. Additionally, an analytical method is applied based on neutrons collisions and mathematical equations to estimate absorbed doses. Finally, the results obtained from two methods are compared to each other to justify the approach.

Development of Dendrimer Encapsulated Radio-Ytterbium and Biodistributionin Tumor Bearing Mice.

The aim of this study is preparation of dendrimer encapsulated ytterbium-175 radio-nanoparticles and investigation of the compound chemical characteristic before and after the neutron irradiation and also study the in vivo biodistribution for targeted radiopharmaceutical dose delivery to solid tumors. For preparation of dendrimer-metal nanocomposite, a dendrimer compound containing an average of 55 Yb ions per dendrimer was prepared. The synthesized encapsulated ytterbium irradiated by neutron for 2 h at 3×10 n.