Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta.

The aim of this study was to point out the potential of tartary buckwheat on vascular functions. A nonabsorbed fraction of hot-water extract of tartary buckwheat on a SP70 column (TBSP-T), which was free from rutin, was used for this aim. In a contractile experiment using Sprague-Dawley rat thoracic aorta rings contracted by 1.

Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril.

Effects of long-term sarpogrelate (5-HT(2) antagonist) administration on the systolic blood pressure of Wistar-Kyoto normotensive rats (WKYs) and spontaneously hypertensive rats (SHRs) were studied and compared with those of quinapril (ACE-I). Sarpogrelate and quinapril were administered orally for 12 weeks and body and heart weights, systolic blood pressure and the relationships between heart weight and systolic blood pressure were determined. Although both drug treatments caused decreases in the body weight of WKYs and SHRs, only quinapril induced a decrease in the heart weight of SHRs.

Use of dextran-primed extracorporeal circuit in the canine model for venous return: with special references to the effects of two dihydropyridine-type Ca2+ channel blockers.

1. A successful canine "venous return (VR)" model is described, in which all hemodynamic parameters were stable for about an hour, by minimizing extracorporeal circuit primed with dextran (DX) so that the dilution of the blood was kept about 33%. 2.

Effects of sodium nitroprusside (MR7S1) and nitroglycerin on the systemic, renal, cerebral, and coronary circulation of dogs anesthetized with enflurane.

In beagle dogs anesthetized with enflurane-nitrous oxide, effects of sodium nitroprusside (SNP; MR7S1) and nitroglycerin (NTG) on hemodynamics and main organ circulation were studied to evaluate their effectiveness and safety as hypotensive agents during anesthesia. SNP (MR7S1) infusion (1-10 micrograms/kg/min) decreased arterial blood pressure in a dose-dependent manner. The hypotension was stable during the infusion.

Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs.

Hemodynamic effects and inhibitory effects on the pressor response to exogenous angiotensin I of benazepril (CGS 14824A), a new angiotensin-converting enzyme (ACE) inhibitor, were examined in conscious chronically instrumented normotensive dogs in comparison with those of captorpil. Oral administration of benazepril (1-10 mg/kg) and captopril (3 and 10 mg/kg) reduced the blood pressure and inhibited the pressor response to angiotensin I dose-dependently. The blood-pressure-lowering effect of benazepril was as potent as that of captopril.

Effects of calcium antagonists, felodipine and nicardipine, on cerebral circulation in dogs.

The effects of a calcium antagonist of the dihydropyridine type, felodipine, on the cerebral circulation were studied in comparison with those of nicardipine in pancuronium-bromide immobilized unanesthetized dogs. Felodipine (0.3-10 micrograms/kg, i.

Effects of chronic oral administration of a new beta-blocker, bopindolol, on serum lipoprotein concentrations and blood pressure of spontaneously hypertensive rats.

The effects of chronic oral administration of bopindolol (twice daily for 12 weeks beginning at 5 weeks of age) on serum lipoprotein concentrations, blood pressure and heart rate, were studied in spontaneously hypertensive rats. They were compared with those of two other beta-blockers. Bopindolol and propranolol (15 mg/kg) attenuated the increase in heart rate.

Partial agonist activity of celiprolol as assessed in conscious unrestrained dogs in comparison with those of pindolol and labetalol.

The effects of celiprolol on the heart rate (HR) and the total peripheral resistance (TPR) were studied in chronically instrumented conscious dogs in comparison with those of pindolol, propranolol and labetalol. Intravenous injection of pindolol, celiprolol and labetalol increased the HR and decreased the TPR dose-dependently, whereas propranolol did not. The ratios of doses that elicited 12% changes in both parameters (HR12/TPR12) were 4.

Cardiohemodynamic effects of bopindolol in normotensive conscious dogs. A comparative study with pindolol.

Cardiohemodynamic effects and the beta-blocking action of a new beta-adrenoceptor blocking agent, bopindolol (Sandonorm) were compared with those of pindolol in conscious unrestrained dogs. The intravenous injection of pindolol (3-100 micrograms/kg) increased the heart rate and decreased the total peripheral resistance dose-dependently and markedly, while the same doses of bopindolol had no effect on the heart rate and decreased the total peripheral resistance only at the maximum dose (100 micrograms/kg). These changes were antagonized by propranolol (3 mg/kg).

[The hypotensive effects and mechanism of SGB-483, a newly-synthesized hypotensive agent].

The effects of SGB-483, a newly-synthesized hypotensive agent, on the blood pressure were studied in unanesthetized and anesthetized rats. SGB-483 produced a significant hypotensive action in the conscious SHR and renal hypertensive (clipping) rats, and it caused reversal of the pressor response to adrenaline in the anesthetized Wistar-Imamichi rats, SHR, and clipping rats. In an isolated guinea pig aorta preparation, SGB-483 competitively inhibited the contractile response to phenylephrine with a pA2 value of 7.

[Antihypertensive effects of labetalol in three types of hypertensive models of rats (author's transl)].

Effects on blood pressure and heart rate of labetalol, a new beta-adrenoceptor blocking agent with alpha-blocking action were studied in conscious hypertensive rats (SHR, DOCA-hypertensive rats and renal hypertensive rats (RHR)). Labetalol with two asymmetric carbon atoms consists of an equal proportion of two racemates. In SHR, prevention of the development of hypertension was noted after 1.

[Antihypertensive effect of guanfacine in rats].

Effects of an antihypertensive drug, guanfacine, on blood pressure and heart rate were studied in comparison with findings in a related drug, clonidine. Conscious rats (normotensive rat, SHR, DOCA-hypertensive rat and renal hypertensive rat), anesthetized rats and pithed rats were used. Effects of guanfacine resembled those of clonidine but were about 10 times less potent.