Changes to spontaneous otoacoustic emissions (SOAEs) due to cisplatin administration.

We investigated the influence of cisplatin on spontaneous otoacoustic emissions (SOAEs) by measuring SOAEs, before and after cisplatin administration, in 18 ears of nine patients (one female and eight males) who had received chemotherapy with cisplatin for a brain tumor. No hearing loss was observed after cisplatin administration in eight ears. Before cisplatin administration SOAE was present in four out of these eight ears, and only mild frequency fluctuation was observed even after administration.