Trastuzumab-Mediated Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Enhances Natural Killer Cell Cytotoxicity in HER2-Overexpressing Ovarian Cancer.

Ovarian cancer is the deadliest gynecologic cancer. Although human epidermal growth factor receptor-2 (HER2) overexpression, a poor prognostic molecular marker in ovarian cancer, is found in almost 30% of ovarian cancer cases, there are no established therapies for HER2-overexpressing ovarian cancer. In this study, we investigated the efficacy of combined samfenet, a biosimilar compound of trastuzumab, and natural killer (NK) cells in preclinical model of HER2-overexpressing ovarian cancer.

Impacts of hot electron diffusion, electron-phonon coupling, and surface atoms on metal surface dynamics revealed by reflection ultrafast electron diffraction.

Metals exhibit nonequilibrium electron and lattice subsystems at transient times following femtosecond laser excitation. In the past four decades, various optical spectroscopy and time-resolved diffraction methods have been used to study electron-phonon coupling and the effects of underlying dynamical processes. Here, we take advantage of the surface specificity of reflection ultrafast electron diffraction (UED) to examine the structural dynamics of photoexcited metal surfaces, which are apparently slower in recovery than predicted by thermal diffusion from the profile of absorbed energy.

Biosynthesis of JC-LaCoO magnetic nanoparticles explored in catalytic and SMMs properties.

We have reported the synthesis of JC-LaCoO magnetic nanoparticles from Jatropha Curcas L. leaf extract in aqueous medium and potential application study in catalytic & Single Molecule Magnets (SMMs). Several techniques were used to investigate the structural, morphological, and elemental composition, particle size, optical properties, catalytic and magnetic properties by XRD, FTIR, SEM, EDAX, XPS, UV-visible and squid magnetic measurement.

PSPC1 Inhibition Synergizes with Poly(ADP-ribose) Polymerase Inhibitors in a Preclinical Model of BRCA-Mutated Breast/Ovarian Cancer.

Poly (ADP-ribose) polymerase (PARP) inhibitors are effective against -mutated cancers through synthetic lethality. Unfortunately, most cases ultimately develop acquired resistance. Therefore, enhancing PARP inhibitor sensitivity and preventing resistance in those cells are an unmet clinical need.

Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer.

Background: Breast cancer is the global leading cancer burden in women and the hormone receptor-positive (HR+) subtype is a major part of breast cancer. Though cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are highly effective therapy for HR+ subtype, acquired resistance is inevitable in most cases. Herein, we investigated the paternally expressed gene 10 (PEG10)-associated mechanism of acquired resistance to CDK4/6 inhibitors.

Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial Cancer.

Endometrial cancer stands as the predominant gynecological malignancy in developed nations. For advanced or recurrent disease, paclitaxel-based chemotherapy is the standard front-line therapy. However, paclitaxel resistance eternally develops.

Therapeutic artifact: Case series.

Artifacts are pervasive in every realm of biological science, and this includes the field of medicine. Unless explicitly recognized by scientific experts, artifacts can be found and may influence research and findings in the medical domain, just as they do in other branches of biological science. Therapeutic artifacts are changes that occur in the body as a result of medical interventions.

Preclinical Platform Using a Triple-negative Breast Cancer Syngeneic Murine Model to Evaluate Immune Checkpoint Inhibitors.

Background/aim: To evaluate the feasibility of syngeneic mouse models of breast cancer by analyzing the efficacy of immune checkpoint inhibitors (ICIs) and potential predictive biomarkers.

Materials And Methods: To establish the murine triple-negative breast cancer (TNBC) models, JC, 4T1, EMT6, and E0771 cells were subcutaneously implanted into female syngeneic mice. When the tumor reached 50-100 mm, each mouse model was divided into a treatment (using a murine PD-1 antibody) and a no-treatment control group.

Tuning the semimetallic charge transport in the Weyl semimetal candidate EuIrO(111) epitaxial thin film with an all-in-all-out spin structure.

We report the stoichiometric epitaxial growth of the EuIrO(111) thin film on YSZ substrate by a two-step solid phase epitaxy (SPE) method. An optimized post-annealing environment of the SPE was superior over the conventional air annealing procedure to get rid of the typical impurity phase, EuO. The thickness-dependent structural study on EuIrO(111) thin films suggests a systematic control of Ir/Eu stoichiometry in our films, which is otherwise difficult to achieve.

Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer.

Epithelial ovarian cancer remains the leading cause of mortality among all gynecologic malignancies owing to recurrence and ultimate development of chemotherapy resistance in the majority of patients. In the chemotherapy-resistant ovarian cancer preclinical model, we investigated whether AZD6738 (an ataxia telangiectasia and Rad3-related (ATR) inhibitor) could synergize with belotecan (a camptothecin analog and topoisomerase I inhibitor). In vitro, both chemotherapy-resistant and chemotherapy-sensitive ovarian cancer cell lines showed synergistic anti-proliferative activity with a combination treatment of belotecan and AZD6738.

Single Molecule Magnets of Co and CoLa MOFs Synthesized by New Schiff Base Ligand N,N'-bis(-Vanillinidene) Ethylenediamine (-VEDH).

Schiff base ligand N,N'-bis(-vanillinidene) ethylenediamine (-VEDH) has been employed to synthesize new [CoCo(-VED)(OAc)(μ-OAc)(OMe)]•MeOH () and [ (-VED)(en)(NCCH)(OCH)][La(NO)]( )•2MeOH•MeCN•HO () metal-organic frameworks (MOFs) that have interesting single molecule magnets (SMMs) property. The synthesized complexes are characterized by single crystal X-ray diffraction, fourier transform infrared spectroscopy (FTIR), UV-visible spectroscopy, and squid magnetic measurement. Single crystal X-ray data show that both complexes crystallize in the monoclinic crystal system with 2/(14) and 2/(14) space groups and generate unique MOF-like structures.

Structures of self-assembled n-alkanethiols on gold by reflection high-energy electron diffraction.

The structures of long-chain alkanethiols (CHSH) chemisorbed on an Au(111) single crystal were investigated using reflection high-energy electron diffraction (RHEED). The primary structure observed as a major species in the as-deposited films contains gold adatoms below the sulfur headgroups. Between the small ordered domains with the alkyl chains tilting toward six directions are azimuthally disorderly packed regions, with a similar average tilt of 30.

Green synthesis of copper nanoparticles from an extract of leaves: characterization, optical properties, CT-DNA binding and photocatalytic activity.

The green synthesis of copper nanoparticles (CuNPs) using a leaf extract from (JC) has been documented in our present research work. The existence of flavonoids, tannins, glycosides, and alkaloids was confirmed by the phytochemical analysis of the plant extract and these chemicals can be used as reducing, stabilizing and capping agents. After six months, the JC-CuNPs were found to be stable without any evidence of agglomeration.

New Dual-Functional and Reusable Bimetallic YZnO Nanocatalyst for Organic Transformation under Microwave/Green Conditions.

A novel bimetallic and reusable YZnO nanocatalyst was synthesized by a simple coprecipitation method. The prepared nanocatalyst exhibited dual catalytic activity and was characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM). The average crystallite and grain sizes were found to be 17 ± 1 and 10 ± 2 nm, respectively.

Synthesis of Two Mononuclear Schiff Base Metal (M = Fe, Cu) Complexes: MOF Structure, Dye Degradation, HO Sensing, and DNA Binding Property.

O-Vanillin and ethylenediamine were used for the synthesis of ,'-bis(O-vanillinidene)ethylenediamine (O-VEDH) Schiff base ligand, which was characterized by UV-visible and H NMR spectroscopy. The Schiff base ligand O-VEDH has been employed to synthesize novel [CHFeNO]NO () and CHCuNO () complexes by the simple slow evaporation method. The single crystals were characterized by X-ray crystallography, as well as Fourier-transform infrared and UV-visible spectroscopy techniques.

The Effects of Aronia melanocarpa 'Viking' Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling.

This study aimed to determine the anti-osteoclastogenic effects of extracts from 'Viking' (AM) and identify the underlying mechanisms in vitro. Reactive oxygen species (ROS) are signal mediators in osteoclast differentiation. AM extracts inhibited ROS production in RAW 264.