Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support.

Objective: To evaluate the efficacy of automatic oxygen control (A-FiO) in reducing the extremes of oxygen saturations (SpO<80% and SpO>98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow.

Design: A parallel-arm randomised controlled trial.

Setting: A level-III neonatal intensive care unit.

Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial.

Objective: The objective of this study was to evaluate the efficacy of the automatic oxygen control (A-Fio) in reducing the percentage of time spent in severe hypoxaemia (Spo <80%) in preterm infants for the time period on invasive ventilation and/or nasal continuous positive airway pressure (NCPAP) delivered by AVEA ventilator.

Design: A parallel arm randomised controlled trial.

Setting: A level-III neonatal intensive care unit.

Automated Oxygen Delivery in Neonatal Intensive Care.

Oxygen is the most common drug used in the neonatal intensive care. It has a narrow therapeutic range in preterm infants. Too high (hyperoxemia) or low oxygen (hypoxemia) is associated with adverse neonatal outcomes.

Outcomes of Preterm Infants Who Experienced Unplanned Extubation.

Background: Unplanned extubation (UE) is associated with adverse outcomes. The aim of the study was to compare the clinical outcomes in preterm infants who experienced at least one UE to those who did not experience any UE.

Methods: The matched cohort study compared ventilated preterm infants < 32 weeks who experienced UE to those who did not experience any UE.

Comparison of volume guarantee and volume-controlled ventilation both using closed loop inspired oxygen in preterm infants: a randomised crossover study (CLIO-VG study).

Objective: The objective of this study was to compare two different modes of ventilation in maintaining oxygen saturation (SpO2) in target range (90%-95%) in ventilated preterm infants cared for with automatic control of oxygen delivery (A-FiO2).

Design: A single-centre randomised crossover study.

Settings: A level III neonatal intensive care unit.

Neonatal listeriosis in the UK 2004-2014.

Objective: To define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement.

Methods: Neonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma.

Automated control of inspired oxygen in ventilated preterm infants: crossover physiological study.

Aim: To evaluate the efficacy of automated control of the fraction of inspired oxygen (FiO2 ) in comparison with manual FiO2 control in maintaining target pulse oxygen saturation (SpO2 ) range.

Methods: Crossover physiological study involving preterm infants requiring mechanical ventilation and supplemental oxygen. Each infant was studied for two consecutive 12 hours in a random sequence.

Automated versus Manual Oxygen Control with Different Saturation Targets and Modes of Respiratory Support in Preterm Infants.

Objective: To determine the efficacy and safety of automated adjustment of the fraction of inspired oxygen (FiO2) in maintaining arterial oxygen saturation (SpO2) within a higher (91%-95%) and a lower (89%-93%) target range in preterm infants.

Study Design: Eighty preterm infants (gestational age [median]: 26 weeks, age [median] 18 days) on noninvasive (n = 50) and invasive (n = 30) respiratory support with supplemental oxygen, were first randomized to one of the SpO2 target ranges and then treated with automated FiO2 (A-FiO2) and manual FiO2 (M-FiO2) oxygen control for 24 hours each, in random sequence.

Results: The percent time within the target range was higher during A-FiO2 compared with M-FiO2 control.

Principles of pulse oximetry and its clinical application in neonatal medicine.

Pulse oximetry is one of the most commonly used monitoring devices in clinical medicine. It was first introduced to neonatal medicine in the mid-1980s to monitor oxygenation and guide therapy, and it is now used widely in the delivery room during resuscitation. More recently, it is utilized to screen for congenital heart disease.

Antenatal corticosteroids and neonatal outcomes according to gestational age: a cohort study.

Objective: To see whether there was any difference in the effect of antenatal corticosteroids on neonatal outcomes according to different gestational ages at birth.

Methods: This was a prospective cohort study in a geographically defined population (Trent region, UK). All infants admitted for neonatal care, of 23-32 weeks' gestation, born to Trent resident mothers over the 15-year period between 1993 and 2007 were included.

Foetal and congenital talipes: interventions and outcome.

Aim: Talipes is a congenital anomaly that can be corrected conservatively or surgically. Despite advances in management, a proportion of pregnancies still result in termination. We therefore aimed to establish the birth prevalence, interventions and outcome of talipes in our population.

Surfactant respiratory therapy using Surfaxin/sinapultide.

Respiratory distress syndrome (RDS) is a leading cause of mortality and morbidity in preterm infants. Surfactant replacement therapy has been widely used to prevent and treat RDS in these newborns and has now become a standard of care. First-generation synthetic surfactants such as Exosurf did not contain any surfactant protein.

Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study.

Objective: To determine the risk of chronic lung disease (CLD) in small for gestational age (SGA) preterm infants in comparison to appropriately grown and large for gestational age (LGA) infants.

Methods: Observational study derived from a geographically defined population (Trent Health Region, United Kingdom). All preterm infants of View Article and Find Full Text PDF

Maternal morbidity and pregnancy outcome in a cohort of mothers transferred out of perinatal centres during a national census.

Objective: To record the maternal morbidity and pregnancy outcome in this cohort.

Design: Retrospective data collection from a prospectively defined cohort.

Setting: The 37 largest perinatal centres in the UK.