Assessment of Different Cetirizine Dosing Strategies on Seasonal Allergic Rhinitis Symptoms: Findings of Two Randomized Trials.

Background: Cetirizine has been shown to be effective for relief of seasonal allergic rhinitis (SAR) symptoms. Allergic rhinitis symptoms have been reported to have circadian variations, with symptoms tending to be most bothersome overnight and in the morning.

Objective: To evaluate the effects of different cetirizine dosing schedules in comparison to twice daily (BID) chlorpheniramine and placebo on SAR symptoms at 12 and 24 hours postdose.

Female Runner With Painful Left Thigh Swelling: A Case of May-Thurner Syndrome.

Unlabelled: We discuss a case of a female runner who presented with burning left groin and thigh pain and positional swelling after a long run. The workup revealed May-Thurner syndrome. May-Thurner syndrome anatomy is a common anatomical variant present in approximately 20% of the population.

Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis.

Background: Pharmacologic treatment is a mainstay of allergy therapy and many caregivers use over-the-counter antihistamines for the treatment of seasonal allergic rhinitis (SAR) symptoms in children.

Objective: To assess the efficacy and safety of cetirizine 10 mg syrup versus loratadine 10 mg syrup versus placebo syrup in a randomized double-blind study of children, ages 6-11 years, with SAR.

Methods: This randomized, double-blind, parallel-group, placebo-controlled study was conducted at 71 U.

Young man with sudden severe hip pain secondary to femoral neck stress fracture.

Femoral neck stress fractures have been described in military recruits and athletes. Early recognition and aggressive treatment are important, as femoral neck stress fractures have a high potential for complications and even uncomplicated fractures require an extensive course of rehabilitation. Tension-side (superolateral) stress fractures of the femoral neck are at high risk for complications such as displacement, non-union and avascular necrosis, and need to be treated surgically, while compression-side (inferomedial) fractures can be treated conservatively.

Neuroleptic malignant syndrome secondary to aripiprazole initiation in a clozapine-intolerant patient.

Purpose: A case of neuroleptic malignant syndrome (NMS) secondary to aripiprazole in a schizophrenic patient previously managed with clozapine is reported.

Summary: A 42-year-old Caucasian woman with a history of schizophrenia (chronic paranoid type) arrived at the emergency department (ED) with a chief complaint of altered mental status and oliguria. The patient was previously managed with clozapine for 14 years, which was well tolerated until the patient developed urinary retention.

Back contouring in weight loss patients.

Background: Body contouring in the post-bariatric surgery patient has focused predominantly on the resulting tissue excesses of the abdomen, breasts, and arms. The back, however, has not received the same attention and, although the skin folds on the back may sometimes be improved by addressing the previously mentioned areas, the result is usually unsatisfactory and leaves the patient with significant residual excess.

Methods: The senior author (B.

A primary protocol for the management of ear keloids: results of excision combined with intraoperative and postoperative steroid injections.

Background: Keloids of the ear are a challenging problem, with many treatment modalities advocated. The primary determinant in choosing a treatment protocol should be a low recurrence rate. Most reports in the literature suffer from small numbers of patients and inadequate follow-up.

Pulsed magnetic fields accelerate cutaneous wound healing in rats.

Background: Previous studies of pulsed magnetic fields have reported enhanced fracture and chronic wound healing, endothelial cell growth, and angiogenesis. This study characterizes the biomechanical changes that occur when standard cutaneous wounds are exposed to radiofrequency pulsed magnetic fields with specific dosage parameters, in an attempt to determine whether return to functional tensile strength could be accelerated in wound healing.

Methods: There were two study phases and a total of 100 rats.

Limited myocardial muscle necrosis model allowing for evaluation of angiogenic treatment modalities.

The currently accepted model for creating infarcted cardiac tissue in a rat model involves ligation of the left anterior descending artery (LAD), either proximally or at the bifurcation level. This procedure requires significant technical expertise and, even in skilled hands, commonly results in a 30% to 60% animal mortality. The authors propose a new model for creating a limited area of myocardial muscle necrosis that can be effectively studied.

Pulsed magnetic field therapy increases tensile strength in a rat Achilles' tendon repair model.

Purpose: To examine the effect of pulsing electromagnetic fields on the biomechanic strength of rat Achilles' tendons at 3 weeks after transection and repair.

Methods: This noninvasive modality was tested in a prospective, randomized, double-blinded, placebo-controlled study to evaluate the effect of a specific noninvasive radiofrequency pulsed electromagnetic field signal on tendon tensile strength at 21 days post transection in a rat model.

Results: In the animals receiving PMF exposure, an increase in tensile strength of up to 69% was noted at the repair site of the rat Achilles' tendon at 3 weeks after transection and repair compared with nonstimulated control animals.