Rationale: Little is known about the consequences of intensivists’ work schedules, or intensivist continuity of care.
Objectives: To assess the impact of weekend respite for intensivists, with consequent reduction in continuity of care, on them and their patients.
Methods: In five medical intensive care units (ICUs) in four academic hospitals we performed a prospective, cluster-randomized, alternating trial of two intensivist staffing schedules.
J Bronchology Interv Pulmonol
October 2010
Drug-induced hepatotoxicity is an infrequent but life-threatening complication. Sunitinib is a multitargeted receptor tyrosine kinase inhibitor approved for treatment of renal cell carcinoma and gastrointestinal stromal tumor. However, results from preapproval clinical trials suggest an equivocal hepatic risk profile for sunitinib.
View Article and Find Full Text PDFBackground: Surfactant abnormalities have been described in bacterial pneumonia.
Objective: To determine the safety and effect of exogenous surfactant replacement in patients with ventilator-associated pneumonia (VAP).
Methods: Patients with VAP were randomized in a double-blind study to receive either an artificial surfactant (Exosurf) consisting mostly of disaturated phospholipids (DSPL) or saline via a continuous nebulizer system for 5 days.