Publications by authors named "Mitchell Kp Lai"
Chronic cerebral hypoperfusion (CCH) is postulated to underlie multiple pathophysiological processes in vascular dementia (VaD), including extracellular matrix dysfunction. While several extracellular matrix proteins, namely cyclophilin A (CypA), extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases (matrix metalloproteinases, MMP-2 and -9) have been investigated in acute stroke, their involvement in CCH and VaD remains unclear. In this study, CypA-EMMPRIN-gelatinase proteins were analysed in a clinical cohort of 36 aged, cognitively unimpaired subjects and 48 VaD patients, as well as in a bilateral carotid artery stenosis mouse model of CCH.
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- The study investigates early alterations in functional network activity in a mouse model (3xTgAD) of Alzheimer's disease, focusing on changes in the entorhinal cortex and its relation to tau pathology.
- Researchers observed resting functional connectivity loss in ventral networks, indicating disrupted brain communication, but found enhanced fMRI signals during active stimulation of the entorhinal cortex.
- The results suggest a complex relationship where these 3xTgAD mice exhibit both reduced connectivity during rest and increased responsiveness when active, highlighting the relevance of this model for understanding early Alzheimer's disease in humans.