Exploring the Potential Health Impact and Cost-Effectiveness of AIDS Vaccine within a Comprehensive HIV/AIDS Response in Low- and Middle-Income Countries.

Background: The Investment Framework Enhanced (IFE) proposed in 2013 by the Joint United Nations Programme on HIV/AIDS (UNAIDS) explored how maximizing existing interventions and adding emerging prevention options, including a vaccine, could further reduce new HIV infections and AIDS-related deaths in low- and middle-income countries (LMICs). This article describes additional modeling which looks more closely at the potential health impact and cost-effectiveness of AIDS vaccination in LMICs as part of UNAIDS IFE.

Methods: An epidemiological model was used to explore the potential impact of AIDS vaccination in LMICs in combination with other interventions through 2070.

Perspectives on HIV prevention: priorities for a new era.

The field of biomedical HIV prevention has undergone remarkable changes over the past 5 years. These advances have expanded conceptions of what should belong in the prevention "toolbox," particularly for infection via sexual exposure. New findings have also added complexity to previous theoretical discussions about plans for introduction and access to these interventions.