Publications by authors named "Mitchell J Lipke"
Article Synopsis
- - The study evaluated the performance of ten quick lateral flow assays and two lab-based tests for detecting antibodies against SARS-CoV-2, focusing on the time after symptom onset and previous test samples.
- - It found that seropositivity increased over time, peaking over 20 days after symptoms began, but test specificity varied between 84.3% and 100%, mainly influenced by IgM results.
- - Recommendations from the study emphasize optimizing seropositivity thresholds and ensuring proper reader training to improve the reliability of these assays, with four tests showing over 80% positivity and over 95% specificity in later time intervals.
Background: Serological tests are crucial tools for assessments of SARS-CoV-2 exposure, infection and potential immunity. Their appropriate use and interpretation require accurate assay performance data.
Method: We conducted an evaluation of 10 lateral flow assays (LFAs) and two ELISAs to detect anti-SARS-CoV-2 antibodies.