Publications by Mitchell Hutmacher

Publications by authors named "Mitchell Hutmacher"

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CRISPR-Cas "Non-Target" Sites Inhibit On-Target Cutting Rates.

Eirik A Moreb Mitchell Hutmacher Michael D Lynch

CRISPR J

December 2020

CRISPR-Cas systems have become ubiquitous for genome editing in eukaryotic as well as bacterial systems. Cas9 forms a complex with a guide RNA (gRNA) and searches DNA for a matching sequence (target site) next to a protospacer adjacent motif (PAM). Once found, Cas9 cuts the DNA.

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