Publications by authors named "Mitchell Haut"
Article Synopsis
- Immune checkpoint inhibition therapy has shown promise for improving outcomes in advanced non-small cell lung cancer, but there's a need for better predictive biomarkers; a blood test called host immune classifier (HIC) was evaluated for this purpose in a real-world study.* -
- The INSIGHT study enrolled over 3,570 NSCLC patients and assessed their survival based on HIC designation (HIC-H or HIC-C) and treatment type, revealing that HIC-H patients had significantly longer overall survival compared to HIC-C patients across various treatment regimens, including ICI therapies.* -
- The findings indicate that HIC testing can independently predict patient survival outcomes regardless of the programmed death ligand 1 (PD-L1)
Unlabelled: Hereditary cancer syndromes infer high cancer risks and require intensive surveillance. Identification of high-risk individuals among patients with colorectal cancer (CRC) needs improvement.
Methods: Three thousand three hundred ten unselected adults who underwent surgical resection for primary invasive CRC were prospectively accrued from 51 hospitals across Ohio between January 1, 2013, and December 31, 2016.
Importance: Hereditary cancer syndromes infer high cancer risks and require intensive cancer surveillance, yet the prevalence and spectrum of these conditions among unselected patients with early-onset colorectal cancer (CRC) is largely undetermined.
Objective: To determine the frequency and spectrum of cancer susceptibility gene mutations among patients with early-onset CRC.
Design, Setting, And Participants: Overall, 450 patients diagnosed with colorectal cancer younger than 50 years were prospectively accrued from 51 hospitals into the Ohio Colorectal Cancer Prevention Initiative from January 1, 2013, to June 20, 2016.