Publications by authors named "Mitchell Campbell"

Article Synopsis
  • Research shows mixed long-term effects on intergroup relations, prompting the creation of an "Inclusivity Page" with pro-diversity messages to enhance classroom environments.
  • The study involved a randomized trial with 1,799 students, measuring course grades, GPAs, and conducting follow-up surveys.
  • Results indicated that underrepresented students exposed to the intervention reported improved grades and GPAs, along with enhanced belonging and better health outcomes among all marginalized groups.
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Article Synopsis
  • This study is a case-control research aimed at creating a classification system for different types of degenerative changes and failures at the proximal junction after spinal surgery.
  • The system outlines four degeneration types: Type 1 (multilevel symmetrical collapse), Type 2 (single adjacent level collapse), Type 3 (fracture), and Type 4 (spondylolisthesis), based on data from patients who had spinal fusion.
  • Findings reveal that degeneration affects nearly half of the patients, with Type 3 having the shortest time before needing revision surgery, while Type 1 shows the lowest revision rate, indicating varying risks associated with each type.
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  • This study utilized a longitudinal observational cohort design to assess the effectiveness of Quantitative Romberg measurements in evaluating balance outcomes before and after surgery in patients with cervical spondylotic myelopathy (CSM).
  • It involved 27 patients who underwent pre- and postoperative testing to measure center of pressure (COP) motion while standing with their eyes open and closed, revealing significant improvements in balance metrics post-surgery.
  • The results indicate that Quantitative Romberg testing offers an objective way to measure balance recovery in CSM patients, potentially guiding future surgical decisions and patient management.
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Discrimination has persisted in our society despite steady improvements in explicit attitudes toward marginalized social groups. The most common explanation for this apparent paradox is that due to implicit biases, most individuals behave in slightly discriminatory ways outside of their own awareness (the dispersed discrimination account). Another explanation holds that a numerical minority of individuals who are moderately or highly biased are responsible for most observed discriminatory behaviors (the concentrated discrimination account).

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There is a dearth of empirically validated pro-diversity methods that effectively create a more inclusive social climate. We developed two scalable interventions that target people's perceptions of social norms by communicating to them that their peers hold pro-diversity attitudes and engage in inclusive behaviours. We tested the interventions in six randomized controlled trials at a large public university in the United States (total n = 2,490).

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Prejudice researchers have proposed a number of methods to reduce prejudice, drawing on and, in turn, contributing to our theoretical understanding of prejudice. Despite this progress, relatively few of these methods have been shown to reliably improve intergroup relations in real-world settings, resulting in a gap between our theoretical understanding of prejudice and real-world applications of prejudice-reduction methods. In this article, we suggest that incorporating principles from another field, social marketing, into prejudice research can help address this gap.

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Article Synopsis
  • The study aims to determine the Minimum Clinically Important Difference (MCID) and Substantial Clinical Benefit (SCB) for various outcome measures like the Neck Disability Index (NDI) and SF-36 in patients undergoing cervical spine fusion.
  • It involved 505 patients with degenerative spine conditions, using longitudinal data and at least one year of follow-up to assess treatment effectiveness.
  • The researchers used ROC curve analysis, with a specific health transition question from the SF-36 as an anchor, to define MCID and SCB values based on patient-reported health improvements.
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Treatment of multilevel cervical myelopathy remains a challenge. We report on a large series of cervical myelopathy patients treated with instrumented open-door laminoplasty. We retrospectively examined the medical records of 104 patients who had undergone instrumented open-door laminoplasty (titanium plate) for cervical myelopathy (minimum follow-up, 24 months).

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Study Design: Retrospective evaluation of perioperative complications with recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge (rhBMP-2/ACS) versus iliac crest bone graft (ICBG) for instrumented posterior cervical fusion.

Objective: To determine the risk of perioperative complications using rhBMP-2/ACS for posterior cervical fusion compared with ICBG.

Summary Of Background Data: There is substantial use of rhBMP-2/ACS as a bone graft substitute for spine fusions outside the Food and Drug Administration-approved indication of anterior lumbar interbody fusion.

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Study Design: Prospective longitudinal cohort.

Objective: This study evaluated the effect of preoperative Mental Component Summary (MCS), preoperative Physical Component Summary (PCS), preoperative Oswestry Disability Index (ODI), back pain predominance, body mass index (BMI), age, smoking status, and workers' compensation on health-related quality of life after lumbar fusion. These factors were selected as they are readily available and may influence a surgeon's decision-making process.

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Study Design: Randomized clinical trial.

Objective: To perform a cost-utility analysis using actual cost data from a randomized clinical trial of patients over 60 years old who underwent posterolateral fusion using either rhBMP-2/ACS or iliac crest bone graft (ICBG).

Summary Background Data: Bone morphogenetic protein has been shown to be an effective bone graft substitute for spine fusion.

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Study Design: Prospective randomized controlled trial of rhBMP-2/ACS (Infuse bone graft) versus iliac crest bone graft (ICBG) for lumbar spine fusion in patients over 60 years of age.

Objective: To report on clinical, radiographic, and economic outcomes, at 2-year follow-up, in patients treated by posterolateral lumbar fusion with rhBMP-2/ACS versus ICBG.

Summary Of Background Data: RhBMP-2/ACS is widely used "off-label" for posterolateral spinal fusion.

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Article Synopsis
  • This randomized clinical trial aimed to determine if using a cervical collar after single-level anterior cervical fusion with plating enhances fusion rates and clinical outcomes.
  • Patients were divided into two groups (Braced and Nonbraced) and assessed using various outcome measures, including pain scores and disability indices, over a 24-month period.
  • Results indicated no significant differences in clinical outcomes or fusion rates between the two groups, suggesting that cervical collars may not be necessary for improved recovery after this surgery.
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Background: One of the primary difficulties in evaluating the effectiveness of lumbar fusion is that, with the exception of spondylolisthesis, specific diagnostic indications for surgery are poorly defined. Diagnostic specificity beyond the symptom of low back pain or the presence of lumbar degeneration needs to be delineated such that outcomes data can be effectively translated into clinical decision making or evidence-based guidelines.

Purpose: The purpose of this study was to report on prospectively collected clinical outcome measures, stratified by diagnosis, among a series of patients with lumbar degenerative disease whose treatment included lumbar spine fusion.

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Study Design: Case report.

Objective: To present 2 cases of fracture-dislocations of the lumbar spine associated with injury to the aorta and avulsion of the cauda equina and present recommendations regarding urgent management of these injuries.

Summary Of Background Data: The "seat-belt syndrome" was first described by Garrett and Braunstein in 1962 to describe intraabdominal visceral injuries with fractures of the lumbar spine.

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Article Synopsis
  • This study investigated the safety of reusing recombinant bone morphogenetic protein (rhBMP-2) in spine surgeries, focusing on potential wound-related complications and allergic reactions.
  • An analysis of 96 patients showed no significant increase in complications during their first and second surgeries with rhBMP-2, despite the presence of some wound issues.
  • The findings suggest that using rhBMP-2 multiple times is generally safe, as there were no allergic reactions and no complications noted in a subset of patients undergoing a third surgery.
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Background Context: Older patients are often advised that their age is a contraindication to lumbar fusion surgery. There is, however, limited available data to support or contradict this assertion. Although prior studies of surgical treatment for lumbar degenerative disease suggest that older patients obtain symptomatic pain relief, an evaluation of fusion outcomes based on modern Health-Related Quality of Life (HRQOL) measures is lacking.

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Background Context: There is mounting evidence supporting the efficacy of bone morphogenetic protein (BMP) for both anterior interbody and posterolateral lumbar fusion. However, the relative cost of BMP remains an important concern for physicians, hospitals, and payers.

Purpose: The purpose of this study is to report on the perioperative costs for patients treated with rhBMP-2 as compared with an iliac crest bone graft (ICBG) supplemented with graft extenders.

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Article Synopsis
  • The study aimed to find a key spinal canal measurement that could predict how well patients with spinal stenosis would respond to epidural steroid injections (ESI).
  • Researchers analyzed CT scans of patients before receiving ESI, measuring different canal dimensions and comparing groups who either improved or needed surgery afterward.
  • Results showed no significant differences in canal dimensions or ratios between patients who improved and those who required surgery, leading to the conclusion that spinal canal size does not predict the success of ESI in spinal stenosis patients.
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Background Context: INFUSE has been proven effective in conjunction with threaded cages and bone dowels for single-level anterior lumbar interbody fusion (ALIF). The published experience with posterolateral fusion, although encouraging, utilizes a significantly higher dose and concentration of recombinant human bone morphogenic protein-2 (rhBMP-2) and a different carrier than the commercially available INFUSE.

Purpose: To present an assessment of fusion rate for posterolateral spine fusion with INFUSE Bone Graft.

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The purpose of this study was to develop and validate a classification of indications for fusion in lumbar degenerative disease. Nineteen spine surgeons reviewed a series of 32 case histories and selected the indication for fusion based on an outlined classification system. To determine the degree of interrater variability, K coefficients were calculated (K for all 32 cases, 0.

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Background Context: Posterior fusion has been advocated as the most effective treatment of anterior cervical pseudoarthrosis. Authors cite the benefits of increased stability and avoiding the risk of dissection through anterior scar tissue. Despite these advantages, posterior fusion is a more extensive procedure from the standpoint of perioperative and postoperative recovery.

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Study Design: A retrospective review of patients who underwent an anterior cervical fusion using recombinant human bone morphogenetic protein (rhBMP)-2 with an absorbable collagen sponge (INFUSE; Medtronic Sofamor Danek, Minneapolis, MN).

Objective: To ascertain the complication rate after the use of high-dose INFUSE in anterior cervical fusions.

Summary Of Background Data: The rhBMP-2 has been primarily investigated in lumbar spine fusions, where it has significantly enhanced the fusion rate and decreased the length of surgery, blood loss, and hospital stay.

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