Publications by authors named "Mitchell C Fuller"

Purpose Of Review: This is a comprehensive review of the literature regarding Lemborexant for the treatment of insomnia. It covers the background and management of insomnia and then reviews the body of existing evidence evaluating the use of Lemborexant for this purpose.

Recent Findings: Insomnia leads to significant decreased in quality of life and economic burden due to decreased workplace performance and increased health care costs.

View Article and Find Full Text PDF

Purpose Of Review: This is a comprehensive review of the literature regarding the use of Solriamfetol for excessive daytime sleepiness. It covers the background and current therapeutic approaches to treating excessive daytime sleepiness, the management of common comorbidities, and the existing evidence investigating the use of Solriamfetol for this purpose.

Recent Findings: Excessive daytime sleepiness leads to worse quality of life, a medical sequela and significant economic cost.

View Article and Find Full Text PDF

Introduction: Opioids are often a mainstay of managing postsurgical pain. Persistent use of opioids for more than 90 days after surgery is problematic, and the incidence of this adverse outcome has been reported in the civilian population ranging from 0.4% to 7%.

View Article and Find Full Text PDF

Chronic pelvic pain (CPP) in women is defined as noncyclical and persistent pain lasting more than six months perceived to be related to the pelvis. There are many etiologies that can cause CPP, including gynecologic, urologic, gastrointestinal, musculoskeletal, neurologic, and psychosocial. There is a strong association between psychological factors and CPP.

View Article and Find Full Text PDF
Article Synopsis
  • Folic acid is essential for regulating homocysteine (Hcy) levels, which are linked to cardiovascular health and can be lowered by daily supplementation.
  • A literature review was conducted on the impact of folic acid on various diseases, focusing on its role in reducing Hcy and its associated health risks.
  • The article concludes that individuals with elevated Hcy should consider folic acid supplementation early on, as it is readily available and may help decrease the risk of vascular disease and other health issues.
View Article and Find Full Text PDF

Purpose Of Review: The human gut microbiome is involved in a bi-directional communication pathway with the central nervous system (CNS), termed the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to mediate or modulate various central processes through the vagus nerve. The microbiota-gut-brain axis is involved with the production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior.

View Article and Find Full Text PDF

Purpose Of Review: Acute postoperative pain reduction is a major target against the opioid crisis. While opioids have traditionally been the mainstay for postoperative analgesia, current practice has focused on a multimodal approach to pain control, including ultrasound-guided blocks with longer acting local anesthetic agents.

Recent Findings: Non-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam, are an important class of medications utilized to manage pain in the perioperative period.

View Article and Find Full Text PDF