Clinical Evaluation of Safety and Efficacy of a Central Current Good Manufacturing Practices Laboratory Produced Autologous Adipose-Derived Stromal Vascular Fraction Cell Therapy Product for the Treatment of Knee Osteoarthritis.

Knee osteoarthritis (KOA) is a prevalent condition characterized by the progressive deterioration of the entire joint and has emerged as a prominent contributor to disability on a global scale. The nature of the disease and its impact on joint function significantly limit mobility and daily activities, highlighting its substantial influence on patients' overall well-being. Stromal vascular fraction (SVF) is a heterogenous, autologous cell product, containing mesenchymal stem cells, derived from the patient's subcutaneous adipose tissue with demonstrated safety and efficacy in the treatment of KOA patients.

Conventional versus computer-assisted technique for total knee arthroplasty: a minimum of 5-year follow-up of 200 patients in a prospective randomized comparative trial.

In the literature, studies of computer-assisted total knee arthroplasty (TKA) after mid-term period are not conclusive and long-term data are rare. In a prospective, randomized, comparative study 100 conventional TKAs (group REG) were compared with 100 computer-assisted TKAs (group NAV). Minimum follow-up was 5years.

Early clinical results of a high-flexion, posterior-stabilized, mobile-bearing total knee arthroplasty: a US investigational device exemption trial.

Between May 2001 and June 2004, 388 total knee arthroplasty cases were enrolled in a prospective, randomized, multicenter investigational device exemption trial. Patients received either the investigational high-flexion mobile-bearing knee or a fixed-bearing control. At 2 to 4 years of follow-up, results in 293 patients with degenerative joint disease were compared using Knee Society Assessment and Function scores, radiographic results, complications analysis, and survival estimates.

Comparison of two minimally invasive implantation instrument-sets for total knee arthroplasty.

Several choices of instrument systems are available for minimally invasive surgical approaches. There are reports that one alternative, the quadriceps sparing, side-cutting instrumentation, results in diminished implantation accuracy. A total of 108 patients were randomized to undergo TKA either using side-cutting implant instrumentation (Group A) or anterior-posterior mini-incision instrumentation (Group B).

Accuracy of side-cutting implantation instruments for total knee arthroplasty.

A new generation of implantation instruments were developed for quadriceps sparing surgical approaches during total knee arthroplasty (TKA). There is little information on the accuracy of the bone cuts performed with the side-cutting technique. A total of 100 patients were randomized to undergo computer-assisted TKA or non-navigated TKA using a mini-subvastus surgical approach and side-cutting implant instrumentation.

Femoral fracture through a previous pin site after computer-assisted total knee arthroplasty.

Computer-assisted total knee arthroplasty has been gaining popularity given the proposed benefits of increased accuracy of the femoral and tibial cuts, quantitative feedback on soft tissue balancing, and the potential for performing the procedure through smaller incisions with decreased soft tissue trauma. Most navigation systems require femoral and tibial threaded pin insertion for placement of guidance trackers, which when removed leave behind defects in the bone that may act as stress risers. We present 2 cases of a femoral fracture through a previous pin site where a guidance tracker had been placed for computer-assisted total knee arthroplasty.

Results of unicompartmental knee arthroplasty at a minimum of ten years of follow-up.

Background: There is a renewed interest in unicompartmental knee arthroplasty. The present report describes the minimum ten-year results associated with a unicompartmental knee arthroplasty design that is in current use.

Methods: Sixty-two consecutive unicompartmental knee arthroplasties that were performed with cemented modular Miller-Galante implants in fifty-one patients were studied prospectively both clinically and radiographically.

The progression of patellofemoral arthrosis after medial unicompartmental replacement: results at 11 to 15 years.

This study reports the 11-year to 15-year results of unicompartmental knee arthroplasty with an emphasis on failure mechanisms and progression of patellofemoral arthrosis. In a prospective study of 513 consecutive potential knee replacement candidates, 59 patients (12%) had medial unicompartmental arthroplasty of the knee. All 59 patients had isolated unicompartmental disease without clinical symptoms or radiographic evidence of patellofemoral arthritis.

Extended trochanteric osteotomy in complex primary total hip arthroplasty. A brief note.

Background: The extended trochanteric osteotomy has been a useful approach for patients undergoing revision total hip arthroplasty; however, it has not been well described as an approach for those undergoing complex primary total hip arthroplasty. The purpose of the present report is to describe our experience with the use of an extended trochanteric osteotomy for patients undergoing complex primary total hip arthroplasty.

Methods: Six patients underwent primary total hip arthroplasty with use of an extended trochanteric osteotomy.

Affective and sensory dimensions of back pain.

Pain words used to communicate suffering were analyzed to identify specific dimensions of back pain. The words were obtained from a group of 131 patients suffering from back pain who described their discomfort on a standardized 87-item pain questionnaire. The results indicate that words descriptive of back pain are not associated in completely random ways.