ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction.

DJ-1 is a redox-sensitive chaperone with reported antioxidant and anti-inflammatory properties in the kidney. The 20 amino acid (aa) peptide ND-13 consists of 13 highly conserved aas from the DJ-1 sequence and a TAT-derived 7 aa sequence that helps in cell penetration. This study aimed to determine if ND-13 treatment prevents the renal damage and inflammation associated with unilateral ureter obstruction (UUO).

Evaluation of an improved sustained-release buprenorphine formulation for use in mice.

Objective: To evaluate analgesic effects of an improved sustained-release buprenorphine (BUP-SR) formulation administered to mice.

Animals: 36 male Swiss-Webster mice.

Procedures: Mice were assigned to each of 3 treatment groups (n = 12 mice/group).