Genotype by environment interactions for chronic wasting disease in farmed US white-tailed deer.

Despite implementation of enhanced management practices, chronic wasting disease in US white-tailed deer (Odocoileus virginianus) continues to expand geographically. Herein, we perform the largest genome-wide association analysis to date for chronic wasting disease (n = 412 chronic wasting disease-positive; n = 758 chronic wasting disease-nondetect) using a custom Affymetrix Axiom single-nucleotide polymorphism array (n = 121,010 single-nucleotide polymorphisms), and confirm that differential susceptibility to chronic wasting disease is a highly heritable (h2= 0.611 ± 0.

Accurate Genomic Predictions for Chronic Wasting Disease in U.S. White-Tailed Deer.

The geographic expansion of chronic wasting disease (CWD) in U.S. white-tailed deer () has been largely unabated by best management practices, diagnostic surveillance, and depopulation of positive herds.