Difference between the epicondylar and cylindrical axis of the knee.

Locating the true flexion-extension axis of the knee can play an important role in component placement in a total knee arthroplasty, especially using contemporary computer-assisted surgical navigation. We determined if the commonly used transepicondylar axis is an accurate and reproducible substitute for the flexion-extension axis. Twenty-three fresh-frozen cadaveric distal femurs with intact soft tissue were imaged with computed tomography and reconstructed in three-dimensional virtual space.