Publications by authors named "Mitasha S Palha"
J Pharmacol Exp Ther
September 2024
Article Synopsis
- Primaquine and Tafenoquine are the only drugs that can cure malaria completely, but they pose risks for individuals with G6PD deficiency, potentially causing severe blood cell damage.
- The study introduces a new mouse model replicating a specific human G6PD variant, allowing researchers to observe how a metabolite called 5,6-POQ affects red blood cells.
- The research indicates that 5,6-POQ is not just a harmless byproduct of drug metabolism but actively contributes to the destruction of older red blood cells in G6PD-deficient individuals, challenging previous assumptions about its role.
