4-Cl-edaravone and ()-2-chloro-3-[()-phenyldiazenyl]-2-butenoic acid are the specific reaction products of edaravone with hypochlorite.

3-Methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is a synthetic one-electron antioxidant used as a drug for treatment against acute phase cerebral infarction in Japan. This drug also reacts with two-electron oxidants like peroxynitrite to give predominantly 4-nitrosoedaravone but no one-electron oxidation products. It is believed that this plays a significant role in amelioration of amyotrophic lateral sclerosis.

Diaryl-λ-chloranes: Versatile Synthesis and Unique Reactivity as Aryl Cation Equivalent.

We have developed a versatile, high-yield synthesis of diarylchloroniums/λ-chloranes through the reaction of various chloroarenes with readily prepared mesityldiazonium tetrakis(pentafluorophenyl)borate under mild conditions. The scope of the reaction is broad, including ArCl, ArBr, and ArI. The diarylchloroniums/λ-chloranes prepared here show unique reactivity in various respects, enabling intermolecular electrophilic arylation reaction of weak nucleophiles, and chlorane-halogane exchange reaction.

Rhythm generation for food-ingestive movements.

In vitro block preparations of the central nervous system (CNS) are particularly valuable for study of central neuronal mechanisms controlling the respiratory and locomotor rhythms. No comparable in vitro preparation has been described previously, however, for analysis of analogous feeding rhythms. In this chapter, we present such a model.