Estimating the excess lifetime risk of radiation induced secondary malignancy (SMN) in pediatric patients treated with craniospinal irradiation (CSI): Conventional radiation therapy versus helical intensity modulated radiation therapy.

Purpose: To quantify the risk of radiation-induced second malignancies (SMN) in pediatric patients receiving craniospinal irradiation (CSI) either with 3-dimensional conformal radiation therapy (Conv CSI) or tomotherapy helical intensity modulated radiation therapy (Tomo CSI).

Methods And Materials: A novel predictive model that accounts for short- and long-term carcinogenesis was incorporated into our institutional treatment planning system to quantify the lifetime risk of SMN in incidentally irradiated organs. Five pediatric patients previously treated with CSI were studied.

Dosimetric feasibility of sparing the primary site for oropharyngeal squamous cell carcinoma after transoral laser microsurgery in patients with unilateral positive neck nodes.

Purpose: To quantify the effect of sparing the primary site after transoral laser microsurgery (TLM) for oropharyngeal squamous cell carcinoma (OPSCC).

Methods And Materials: We reviewed 4 patients with OPSCC who were treated with TLM and postoperative radiation. All patients had T1 base of tongue primaries with the following N stages: 1 N1; 2 N2a; and 1 N2b.