Publications by authors named "Misti Y Martinez"
J Proteome Res
October 2010
Article Synopsis
- Immunoaffinity depletion using antibodies for high-abundance plasma proteins helps enhance the detection of lower-abundance proteins in shotgun proteomic analyses.
- The study found that both top 7 and top 14 immunodepletion significantly improved the detection of proteins, leading to a 25% increase in identified proteins compared to unfractionated samples.
- However, despite the increases, low-abundance proteins accounted for a small percentage of total identifications, indicating that even with these methods, current mass spectrometry techniques struggle to efficiently identify low-abundance disease-specific biomarkers in plasma.
