Publications by authors named "Misset B"
Indirect calorimetry in canopy mode in healthy subjects: performances of the Q-NRG device compared to the Deltatrac II.
Acta Gastroenterol Belg
February 2025
Background: Extensive validation of the Q-NRG indirect calorimeter in canopy mode, especially against reference devices, is lacking. The aim of this study was to test its agreement in canopy mode with the Deltratrac II, which has always been considered as the gold standard indirect calorimeter in daily practice.
Methods: Healthy volunteers underwent indirect calorimetry with two consecutive assessments, using Q-NRG and Deltatrac II, both in canopy mode, in a random order, after careful calibrations.
Background: COVID-19 has put a huge strain on the healthcare systems worldwide, requiring unprecedented intensive care resources. There is still an unmet clinical need for easily available biomarkers capable of predicting the risk for severe disease. The main goal of this prospective multicenter study was to identify biomarkers that could predict ICU admission and in-hospital mortality.
View Article and Find Full Text PDFBackground: Convalescent plasma (CP) reduced the mortality in COVID-19 induced ARDS (C-ARDS) patients treated in the CONFIDENT trial. As patients are immunologically heterogeneous, we hypothesized that clusters may differ in their treatment responses to CP.
Methods: We measured 20 cytokines, chemokines and cell adhesion markers using a multiplex technique at the time of inclusion in the CONFIDENT trial in patients of centers having accepted to participate in this secondary study.
Nutritional approach of patients with minor burns: A neglected aspect of burn care?
JPEN J Parenter Enteral Nutr
October 2024
Background: It is not rare that intensive care unit (ICU) patients report unusual subjective experiences, ranging from a feeling of harmony with the environment to complex phenomena such as near-death experience (NDE). This 1-year follow-up study investigates the characteristics and potential global impact of the NDE memories recalled by ICU survivors.
Method: We prospectively enrolled 126 adult survivors of a prolonged (>7days) ICU stay (all etiologies), including 19 (15 %) who reported a NDE as identified by the Greyson NDE scale.
Objectives: This report describes the implementation of a clinical debriefing (CD) program in intensive care units (ICU) and analyses its feasibility and its impact on staff well-being.
Design: Observational study.
Setting: From April to September 2023, post-shift CDs were run once a week in 2 out of 7 units in our department, using an adapted version of the DISCOVER-PHASE tool.
Article Synopsis
- - The study investigated how minor burns can lead to increased metabolic rates (measured as measured energy expenditure or mEE) in outpatient adults using indirect calorimetry.
- - A total of 49 patients were evaluated, revealing that about 43% showed signs of hypermetabolism, and their energy intake was significantly lower than their mEE.
- - Findings suggest that patients with minor burns might require more energy than they are consuming, highlighting the importance of monitoring their dietary intake post-injury.
Background: Peripheral nerve injuries (PNI) have been associated with prone positioning (PP) in mechanically ventilated (MV) patients with COVID-19 pneumonia. The aims of this retrospective study were to describe PNI prevalence 3 months (M3) after intensive care unit (ICU) discharge, whether patients survived COVID-19 or another critical illness, and to search for risk factors of PNI.
Results: A total of 55 COVID (62 [54-69] years) and 22 non-COVID (61.
Article Synopsis
- The study explores the effectiveness of hydrocortisone and fludrocortisone treatments in patients with septic shock caused by community-acquired pneumonia (CAP) compared to non-CAP cases.
- It includes data from the phase 3 APROCCHSS trial, which initially tested these treatments across multiple centers in France, focusing specifically on how they impact mortality outcomes.
- Results indicate that patients with CAP may respond differently to these treatments, and various mortality rates and recovery metrics were analyzed to determine the overall benefit of the steroid regimen.
Background: Passive immunization with plasma collected from convalescent patients has been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available regarding the use of convalescent plasma in patients with Covid-19-induced acute respiratory distress syndrome (ARDS).
Methods: In this open-label trial, we randomly assigned adult patients with Covid-19-induced ARDS who had been receiving invasive mechanical ventilation for less than 5 days in a 1:1 ratio to receive either convalescent plasma with a neutralizing antibody titer of at least 1:320 or standard care alone.
Article Synopsis
- Detection dogs were trained to identify SARS-CoV-2 infections by sniffing armpit sweat, with samples collected from confirmed positive and negative patients.
- After a training period of 2-3 months, the dogs exhibited high sensitivity (81%), specificity (98%), and accuracy (95%) in detecting the virus, with validation showing consistent performance.
- The study found a unique scent in SARS-CoV-2 positive sweat linked to various volatiles, and a survey indicated strong public support for using these dogs as a reliable pre-screening tool alongside traditional PCR testing.
There is a growing interest in the quality of work life (QWL) of healthcare professionals and staff well-being. We decided to measure the perceived QWL of ICU physicians and the factors that could influence their perception. We performed a survey coordinated and executed by the French Trade Union of Intensive Care Physicians (SMR).
View Article and Find Full Text PDFIt is unknown if the abnormal acylcarnitine (AC) profile observed early after discharge of a prolonged stay in an intensive care unit (ICU) would persist over time. This prospective observational study aimed to describe the mid-term AC profile evolution in survivors of a prolonged ICU stay (≥7 days). Adults enrolled in our post-ICU follow-up program and who attended the consultation 3 months (M3) after discharge were included.
View Article and Find Full Text PDFObjectives: No consensus criteria describe the medical eligibility of the patients to intermediate care units (IMCUs). In this first part of the UNISURC project, we aimed to develop criteria based on a consensus of physicians from the main specialties involved in IMCU admission decisions.
Design: We selected criteria from IMCU literature, scoring systems and intensive care unit nursing workload.
Background: The level of quadriceps strength (QS) generated in the supine or seated position is not similar. For QS follow-up from intensive care unit (ICU) stay to recovery, getting comparable measures is essential. This study aimed to develop and validate new equations for estimating QS in a given position based on the measurement taken in another one.
View Article and Find Full Text PDFThe acylcarnitine (AC) profile has been shown to be altered in survivors of a prolonged stay in intensive care unit (ICU), with higher short-chain derivates compared to reference ranges. The present study aimed at describing the AC profile of patients surviving a short ICU stay versus patients surviving a >7-day multiple organ dysfunction. Patients discharged from ICU after an elective and non-complicated cardiac surgery (CS) were recruited.
View Article and Find Full Text PDFBackground: Oxidative stress (OS) could cause various COVID-19 complications. Recently, we have developed the Pouvoir AntiOxydant Total (PAOT®) technology for reflecting the total antioxidant capacity (TAC) of biological samples. We aimed to investigate systemic oxidative stress status (OSS) and to evaluate the utility of PAOT® for assessing TAC during the recovery phase in critical COVID-19 patients in a rehabilitation facility.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic, caused by SARS-CoV-2, has significantly disrupted society since late 2019, affecting economic and social activities globally.
- To return to normalcy, it's vital to keep enclosed spaces like classrooms and offices open, which requires understanding how the virus spreads in these environments.
- A systematic review outlines factors influencing airborne transmission indoors and proposes infection risk assessment methods and effective mitigation strategies such as improved ventilation, mask usage, and managing room occupancy.
Background: So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) patients with homogeneous aetiologies, such as cardiac arrest or trauma survivors. The aims of this 1-year prospective and monocentric study were to investigate the incidence of NDE in ICU survivors (all aetiologies) as well as factors that may affect its frequency, and to assess quality of life up to 1 year after enrolment.
Methods: We enrolled adults with a prolonged ICU stay (> 7 days).
Unlabelled: At present, it is not clear if critically ill COVID-19 survivors have different needs in terms of follow-up compared with other critically ill survivors, and thus if duplicated post-ICU trajectories are mandatory.
Objectives: To compare the post-intensive care syndrome (PICS) of COVID-19 acute respiratory distress syndrome and non-COVID-19 (NC) survivors referred to a follow-up clinic at 3 months (M3) after ICU discharge.
Design Setting And Participants: Adults who survived an ICU stay greater than or equal to 7 days and attended the M3 consultation were included in this observational study performed in a post-ICU follow-up clinic of a single tertiary hospital.
Article Synopsis
- The study examines the potential of Krebs von den Lungen 6 (KL-6) as a non-invasive marker for monitoring COVID-19 and predicting post-infection complications like pulmonary fibrosis.
- Researchers analyzed KL-6 levels in 222 COVID-19 patients compared to 70 healthy controls, finding significantly higher levels in infected individuals, which correlated with other disease severity indicators.
- Although KL-6 showed promise as a marker for severity, its relationship with pulmonary function tests was weak, suggesting further research is needed to understand its role in mortality and long-term outcomes.
Background: Nutritional status of patients with disorders of consciousness (DoC) is poorly studied.
Objectives: To evaluate the relationship between nutritional status (body mass index, daily calories intake) and clinical variables (level of consciousness, time since injury, diagnosis, etiology and spastic muscle overactivity; SMO,) in patients with prolonged DoCor emerging. Our main hypotheses are i) patients with lower level of consciousness (UWS) have worse nutritional status compared to patients in minimally conscious state (MCS) and ii) SMO could influence nutritional status.
Background: Although sepsis is a life-threatening condition, its heterogeneous presentation likely explains the negative results of most trials on adjunctive therapy. This study in patients with sepsis aimed to identify subgroups with similar immune profiles and their clinical and outcome correlates.
Methods: A secondary analysis used data of a prospective multicenter cohort that included patients with early assessment of sepsis.