Extraction of magnetic circular dichroism effects from blended mixture of magnetic linear dichroism signals in the cobalt/Scotch tape system.

Circular dichroism (CD) signals revealed in some materials may arise from different origins during measurements. Magnetic field dependent CD (MCD) emanating from the spin-polarized band provides direct insight into the spin-spin interband transitions in magnetic materials. On the contrary, natural CD effects which are artefactual signals resulting from the linear polarization (LP) components during the polarization modulation with a photo-elastic modulator in anisotropic polymer systems were usually observed.

[Hypoxia in malignant tumors the target for clostridial therapeutic gene strategies].

In the fast proliferating malignant tumors which are characterized by abnormal vascularisation develop non oxidized regions of a low oxygen partial pressure (pO2). Because these tumors are unsusceptible to a conventional therapy they were chosen for clostridial therapeutic gene strategies. There were presented different strategies using clostridia as selective vectors of destructive genes, e.

[Clostridium infections in leukemias and malignant neoplasms].

This review describes the subject of clostridial complications in leukemia and malignant neoplasms. These complications include bacteremia and spontaneous nontraumatic gas gangrene of the muscles. The mechanism of anaerobic microenvironment formation, which is necessary for infection development in neoplastic tumors, is also demonstrated.

Esophageal motility impairment--the cause or consequence of gastroesophageal reflux disease?

There are at least three, well-known, different groups of motor activity disturbances of the upper part of alimentary tract which can induce the development of gastroesophageal reflux disease (GERD) and enlarge the risk of excessive exposure of the esophageal mucous membrane on gastric juice and/or biliary contents. Most important is insufficiency of the lower esophageal sphincter (LES), which causes gastroesophageal reflux at 50-60% of patients suffering from GERD. Other reasons include impairment of stomach function (increase of intra-gastric pressure, late emptying and/or hypersecretion), and impairment of esophageal clearance.

The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer.

Aims: To study the efficacy of omeprazole triple therapy in the eradication of Helicobacter pylori in patients with active gastric ulcer, and to assess healing and relapse of gastric ulcer.

Methods: A double-blind, randomized study was carried out in 18 centres in Germany, Hungary and Poland. Patients (n = 160) with gastric ulcer and a positive H.

Topography of Helicobacter pylori infection in gastric cancer patients.

The role of Helicobacter pylori in gastric carcinogenesis is a subject of an increasing interest. In this report we describe a prospective study on the resected stomachs to establish the prevalence of H. pylori in different types of gastric carcinoma.

Does p53 overexpression cause metastases in early invasive colorectal adenocarcinoma?

Objective: To find out whether p53 overexpression correlates with metastatic potential and other adverse prognostic factors in early invasive colorectal carcinoma and whether measurement of the expression of p53 protein could be helpful in the choice of treatment (endoscopic/local or radical resection).

Design: Retrospective study.

Setting: University hospital, Japan.

[Iatrogenic esophageal injuries and their treatment].

In our Department 22 patients were treated due to esophagus perforations in the years 1990-1996. Most of them (16) occurred after endoscopic examinations: diagnostic-3, after strictures dilatation-10, endoscopic intubation-2, sclerotherapy-1, transesophageal cardioversion-1. There were 5 intraoperative perforations: 3-after cardiomyotomy, 2-after intubation.

[Prognostic significance of cellular immunity in surgical treatment of esophageal cancer].

The aim of the study was to investigate the influence of perioperative changes of the cellular immunity parameters on long-term survival following esophagectomy for carcinoma of the esophagus. In 39 patients several immunological parameters have been assessed before and 2 weeks after the operation: WBC, lymphocyte count, lymphocyte T% (E-rosette test), helper/suppressor lymphocyte T subpopulations (teophylline test), NBT test, and in vivo Multitest CMI (skin delayed hypersensitivity for recall antigens). Survival was analyzed using Kaplan-Meier method according to the stage (pTNM, UICC'92) and to the grade of perioperative cellular immunity (pCI) deterioration.

[The effect of Nissen-Rossetti fundoplication on the motor function of swallowing in patients with reflux diseases].

This prospective study was undertaken to assess the motility of the middle and lower esophagus and LES resting pressure changes following the N-R fundoplication for GER. The study was carried out in 53 consecutive patients (37 women, 16 men, median age 49.1 +/- 6.

[Postoperative evaluation of esophageal mucosal change dynamics in patients with reflux diseases].

Comparative value of esophagoscopy and biopsy in correlation with 24 hour esophageal pH metry parameters were assessed in 53 consecutive patients operated on due to GERD. The special attention was paid to the type and intensity of esophageal mucosa injury and the quantity of the pathological gastroesophageal reflux. The therapeutic effect of the Nissen Rossetti fundoplication on postoperative changes in esophageal mucosa was also estimated on the average 18 months after the antireflux procedure.

[Comparison of combined (endoscopic sphincterotomy + laparoscopic cholecystectomy) and classical treatment of obstructive jaundice in the course of cholelithiasis].

Unlabelled: Since August 1993 till December 1996, 672 patients with the gallstone disease were submitted to the laparoscopic cholecystectomy (LC). In 78 (11.7%) of them, the endoscopic sphincterotomy (ES) was performed before LC for the treatment of the coexistent obstructive jaundice caused by bile duct stones (Group I).

[Correlations between risk factors for metastasis in early tumors of the large intestine].

Unlabelled: Intramucosal colorectal cancers (Tis) are treated by local excision. Controversies remain as to the management of patients with the submucosally invasive colorectal cancers (EIC). The decision for radical surgery or local excision depends on an estimate of the risk of metastases.

[Comparison of the usefulness of ultrasonography and computed tomography in diagnosis of acute necrotizing pancreatitis].

The aim of this paper is to evaluate the sensitivity and specificity of ultrasound and computed tomography imaging in necrotizing acute pancreatitis. Since 01'95 till 12'96 we treated 36 patients with acute pancreatitis. They were diagnosed by US and contrast enhanced CT.

[Complications of endoscopic sphincterotomy].

The aim of the study is an analysis of the complications among the patients who underwent endoscopic sphincterotomy. In years 1991-1996 in our Department 412 patients underwent endoscopic sphincterotomy. Bile ducts stones, acute bile pancreatitis, papilla Vateri stricture and the postoperative bile fistula were the indications for the procedure.

[Stomach and esophageal neoplasm. Changes over 16 years in clinical materials].

Increasing prevalence of adenocarcinoma of the esophagus and esophago-gastric junction has been reported. The aim of the study was to determine whether this phenomenon is reflected in the cohort of patients referred for surgery to our institution. Clinical and pathological records of patients with adenocarcinoma of the stomach (n = 433) or gastro-esophageal junction (n = 302), and squamous cell carcinoma of the esophagus (n = 266) were reviewed from 1981 to 1996.

Retroperitoneal tumors.

Retroperitoneal tumors (RPTs) are most commonly found in anatomically confined spaces. Primary RPTs are to be distinguished from those arising from retroperitoneal organs or from the metastatic masses. They may originate either from anyone of the three embryonal leaves or may take on more complex composition, consequently accounting for their varied histological appearance (1, 10).

[The effect of acute ischemia on the small intestine of the dog].

There were carried out macroscopic and microscopic observations of dog's small intestine after putting a clamp on the artery only or on the artery and the upper mesenteric vein. Examinations were performed after 1 and 2 h of ischemia and in different periods after restitution of circulation. By means of histologic and histochemical methods it was found out that no later than after 1 h of ischemia there occur pathologic, irreversible changes in the wall of the small intestine.

[Changes in histochemical reactions in the epithelium of the small intestine of the dog with acute circulatory disorders].

Using histochemical methods for testing the activity of hydrolytic and respiratory enzymes, there were examined changes of the intestinal epithelium caused by acute ischemia which was produced by putting clamps on the upper mesenteric vessels. The changes were stronger after a simultaneous occlusion of the artery and vein and did not repair after restitution of circulation so having irreversible character.

[Effect of partial ileal bypass on the liver lipid level in dogs on an atherogenic diet].

An attempt was undertaken to find out to what extent a partial ileal bypass in healthy dogs fed for 6 and 12 months on overloaded atherogenic diet with an addition of metizol influences the level of lipids and the development of atherosclerosis of the aorta. For the investigations 16 mongrels, both sexes, from 2 to 5 years old were used. an unoperated, control group consisted of 6 dogs, which were fed on the atherogenic diet for 12 months.