MOF-Derived Hollow C, N-Doped CoO Dodecahedral Nanostructure Enwrapped with MgInS Nanosheets for Enhanced Photocatalytic N Reduction.

Design of hierarchical hollow nanoheterostructure materials through interfacial and defect engineering is an innovative approach for achieving optimal charge separation dynamics and photon harvesting efficiency. Herein, we have described a facile technique to fabricate hollow MOF-derived C, N-doped-CoO (C, N-CoO) dodecahedral particles enwrapped with MgInS nanosheets for enhanced N reduction performance. ZIF-67 was initially used as a sacrificial template to prepare hollow C, N-CoO using a carbonization route followed by low-temperature calcination treatment.

Cooling Performance of TiO-Based Radiative Cooling Coating in Tropical Conditions.

The cooling power of radiative cooling (RC) coatings depends not only on the radiative properties of the coating but also on environmental variables. In tropical environments, the cooling performance of RC coatings deteriorates due to high humidity and high solar radiation. Previous studies focused on developing high solar-reflective coatings to achieve subambient cooling in tropical environments.

Recycled Anode Materials from Manufacturing Industry for Anion Exchange Membrane Water Electrolyzer.

As the energy industries, such as secondary batteries and fuel cells, expand rapidly, the demand for transition metals used as electrode materials is increasing, which has led to a rise in their prices. One promising strategy to address these challenges is upcycling, which involves recycling transition metal-based waste from various industries. In this study, a heterostructure electrocatalyst for anion exchange membrane water electrolysis is developed by upcycling iron-based waste from the automotive industry.

Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis.

Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB pathogenesis. Here, we identify two distinct neutrophil populations based on CD101 expression, highlighting their divergent roles in TB. CD101-negative (CD101) neutrophils, which resemble immature, pro-inflammatory granulocytes, exhibit reduced Mtb phagocytosis compared to their mature, CD101-positive (CD101) counterparts.

A Complex Pediatric Vertebrobasilar Junction Aneurysm Treated using a Flow Diverter with Coiling: Case Report and Management Strategy.

Pediatric intracranial aneurysms (PIAs) are highly uncommon, with an incidence of <5% (0.17 to 4.6%) and <2% of PIA complicates into an aneurysmal hemorrhage.

Microbial Diversity and Resistome in Milk of Cows with Subclinical Mastitis in a Coastal District of Odisha, India.

Mastitis is a globally prevalent bacterial disease of lactating cows. Prevention and control of this multi-etiological complex disease relies upon administration of antibiotics. This has led to the emergence of newer multi-drug resistant strains.

Trends of Brain Stimulation Research in Substance Use Disorder: A Review of ClinicalTrials.gov Registered Trials and Their Publications.

Purpose Of The Review: Brain stimulation techniques targeting neuronal pathways are evolving as a novel therapeutic option for substance use disorders. This study aims to provide an overview of the current research landscape on brain stimulation in addiction psychiatry by analyzing data from ClinicalTrials.gov.

Mechanosensing regulates pDC activation in the skin through NRF2 activation.

Plasmacytoid DCs (pDCs) infiltrate the skin, chronically produce type I interferon (IFN-I), and promote skin lesions and fibrosis in autoimmune patients. However, what controls their activation in the skin is unknown. Here, we report that increased stiffness inhibits the production of IFN-I by pDCs.

Bilateral Traumatic Rupture of the Quadriceps Tendon - A Case Report.

Introduction: Quadriceps tendon rupture is a traumatic injury where the quadriceps detaches from the patella, disrupting the knee's extensor mechanism. Bilateral ruptures, first documented in 1949, are rare, with an incidence of 0.17-2.

design and discovery of pan coronavirus small molecule anti-virals targeting 3CL protease.

Coronaviruses (CoV), belonging to the family , were not considered dangerous pathogens until the outbreaks of SARS, MERS, and more recently, COVID-19. The coronaviruses causing these respective diseases/syndromes, SARS, MERS, and SARS-CoV2, share high sequence and structural similarities. COVID-19 continues to have a global impact on human health and the economy.

Covalent Organic Frameworks for Photocatalysis.

The global energy crisis and environmental concerns are driving research into renewable energy and sustainable energy conversion and storage technologies. Solar energy, as an ideal sustainable resource, has significant potential to contribute to the goal of net-zero carbon emissions if effectively harnessed and converted into a reliable and storable form of energy. Photocatalysts have the potential to convert sunlight into chemical energy carriers.

Effect of Size-Controlled Nanofluid on Mechanical Properties, Microstructure, and Rheological Behavior of Cement Slurry for Oil Well Cementing.

The optimal design of cement slurry by balancing various cement additives and cement is critical for effective oil well cementation job. However, given adverse circumstances of application, existing additives may not be sufficient to perform suitably in challenging conditions, leading to premature cement hydration, formation of microcracks, and gas channeling pathways. Thus, this study explores the use of a single-step silica nanofluid (NP size: 5-10, 90-100, and 250-300 nm and concentration: 1, 3, and 5 wt %) as an additive and explores its effect on thickening time, fluid loss, and rheological behavior of class G cement slurry at high-pressure and high-temperature (HPHT) conditions (135 °C and 3625 psi).

Terrein: isolation, chemical synthesis, bioactivity and future prospects of a potential therapeutic fungal metabolite.

The increasing risk of drug-resistant infections and unexpected pandemics like Covid-19 has prompted researchers to explore the area of drug repurposing. Natural products, being a result of the evolutionary optimisation processes can be potential starting points for such drug discovery programs. One such unexplored chemical is terrein, a secondary fungal metabolite.

Tailoring catalysis at the atomic level: trends and breakthroughs in single atom catalysts for organic transformation reactions.

The utilization of precise materials in heterogeneous catalysis will provide various new possibilities for developing superior catalysts to tackle worldwide energy and environmental issues. In recent years, single atom catalysts (SACs) with excellent atom utilization and isolated active sites have progressed dramatically as a thriving sector of catalysis research. Additionally, SACs bridge the gap between homogeneous and heterogeneous catalysts and overcome the limitations of both categories.

Correction: Psychological distress and burnout among healthcare worker during COVID-19 pandemic in India-A cross-sectional study.

[This corrects the article DOI: 10.1371/journal.pone.

Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets.

In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined as combinations of elements whose joint interactions result in the emergence of information that is not present in any individual subset of those elements. The scalability of frameworks such as partial information decomposition (PID) and those based on multivariate extensions of mutual information, such as O-information, is limited by combinational explosion in the number of sets that must be assessed.

Explicit water-ligand docking, drug-likeness and molecular dynamics simulation analysis to predict the potency of plant extract against mutant wilms tumor-1 protein responsible for type 4 nephrotic syndrome.

Thestructure and function of a protein are closely connected. Changes in a protein structure can impact on its function. Nephrotic syndrome type 4 (NPHS4) is an uncommon genetic condition caused by mutations in the WT1 gene, which codes for the wilms tumor-1 protein.

Formulation and evaluation of cetuximab functionalized phospholipid modified nanocrystals of paclitaxel for non-small cell lung cancer therapy.

Present work aims to prepare Soluplus stabilized, phospholipid-modified, and cetuximab-conjugated paclitaxel nanocrystals (NCs) as stable nanocarriers for targeted drug delivery. The NCs, prepared using concurrent antisolvent precipitation cum cold crystallization method followed by probe sonication, were found to be monodispersed particles with sub-200 nm size. The microscopic analysis uncovered rod and spherical anisotropy for Soluplus stabilized (PTX-NCs) and phospholipid modified (Lipid/PTX-NCs) nanocrystals, respectively.

Expanding the phenotyping spectrum of Witteveen Kolk syndrome: first report of generalized dystonia and cerebellar ataxia.

Witteveen-Kolk syndrome (WITKOS) is an autosomal dominant disorder characterized by distinct facial features, microcephaly, short stature, intellectual disability, and subtle neuroimaging abnormalities. The syndrome is attributed to a loss of function mutation in the SIN3A gene, a member of the switch-insensitive 3 transcription regulator family. Herein, we present a 21-year-old woman with dysmorphic facial features, short stature, and a chronic, progressively worsening symmetric cerebellar ataxia, along with generalized dystonia.

CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.

Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with a poorly understood immunopathogenesis. Here, we report that HS lesional skin is characterized by the expansion of innate lymphocytes and T cells expressing CD2, an essential activation receptor and adhesion molecule. Lymphocytes expressing elevated CD2 predominated with unique spatial distribution throughout the epidermis and hypodermis in the HS lesion.

Postoperative Bleeding in a HIV-Positive Patient Operated for Oral Cancer: A Case Report.

Human immunodeficiency virus(HIV) is transmitted sexually, through blood transfusions, sharing intravenous needles, and from the mother to a child during the birth process and breastfeeding. Most of the patients diagnosed with HIV develop AIDS within ten years if left untreated. HIV infected patients have a higher risk of complications than those who are not having the disease.

Histopathological Variants of Oral Squamous Cell Carcinoma Operated at a Cancer Institute in North India.

Conventional oral squamous cell carcinoma (OSCC) is one of the most common cancers of the head and neck region. However, histopathological variants of conventional oral squamous cell carcinoma also exist, which range from highly aggressive to those with good prognosis. Here, we present a case series of different histopathological variants of conventional OSCC treated at our institute.

Early augmentation therapy with dextromethorphan in mild to moderate major depressive disorder: A group sequential, response adaptive randomized controlled trial.

Aim: Therapeutic latency, lack of response, and adverse drug reactions are major challenges in current treatment approaches for major depressive disorder (MDD). Following the success of ketamine, more clinical research on NMDA antagonists is needed for a safe and long-term therapy in MDD. Hence, this study was conducted to evaluate the efficacy and safety of adjunct dextromethorphan to SSRIs in MDD.

An overview of deploying different treatment processes with membrane bioreactor for enhanced treatment of wastewaters: synergistic performances and reduced fouling of membrane.

The membrane bioreactor (MBR) process synergistically combines biological treatment with membrane filtration, offering a compact design and enhanced operational flexibility. However, membrane fouling remains a critical bottleneck, limiting its widespread application, particularly in treating high-strength wastewater. Recent advances have demonstrated that integrating MBR systems with auxiliary processes such as adsorption, electrochemical treatments, algal-assisted systems, and others can significantly mitigate fouling and enhance treatment efficacy.