Publications by authors named "Misha Fotovati"
Article Synopsis
- In vitro fertilization (IVF) is widely used in the U.S. and is becoming more efficient, with some states offering coverage to assist low-income individuals in accessing treatment.! -
- The study assessed whether socioeconomic status affects perinatal outcomes in IVF pregnancies, analyzing data from 10,000 deliveries between 2008 and 2014, focusing on various maternal and neonatal health factors.! -
- Results indicated that socioeconomic status did not significantly influence perinatal outcomes for IVF pregnancies, suggesting that states with IVF coverage may see improved outcomes due to better adherence to recommended practices.!
Background: Despite well-established relationships between sun exposure and skin cancer pathogenesis/progression, specific gene-environment interactions in at-risk individuals remain poorly-understood.
Methods: We leveraged a UK Biobank cohort of basal cell carcinoma (BCC, n = 17,221), cutaneous squamous cell carcinoma (cSCC, n = 2,331), melanoma in situ (M-is, n = 1,158), invasive melanoma (M-inv, n = 3,798), and healthy controls (n = 448,164) to quantify the synergistic involvement of genetic and environmental factors influencing disease risk. We surveyed 8,798 SNPs from 190 DNA repair genes, and 11 demographic/behavioral risk factors.
Basal cell carcinoma (BCC) is the most common form of skin cancer, contributing to nearly a third of new cancer cases in Western countries. Most BCCs are considered low risk "routine" lesions that can either be excised through surgery or treated with chemotherapeutic agents. However, around 1-2% of BCC cases are locally aggressive, present a high risk of metastasis, and often develop chemoresistance, termed advanced BCC.
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