Publications by authors named "Misery L"
This study aimed to evaluate the predictive value of MHC class II (MHC-II) expression by melanoma cells in a large cohort of metastatic cutaneous melanoma patients treated with immune checkpoint inhibitors (ICIs). We conducted a single-center, retrospective study involving stage IV cutaneous melanoma patients who received ICI as first-line therapy. MHC-II expression in melanoma cells was quantified using dual-color anti-SOX10 and anti-MHC-II immunohistochemistry on tumor samples from 95 patients.
View Article and Find Full Text PDFThe objective of this study was to assess the demographic characteristics and impact on quality of life (QoL) of patients with PPG in France through a multicentre study. The results of the study are as follows: The PRO [PUSH-D, PHQ-9 et GAD-7] revealed that more than half of the patients exhibited a significant impact on their quality of life. High scores for fatigue, stress, skin and joint pain were reported, with 65% of patients at risk of mild to severe depression.
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- Atopic dermatitis (AD) significantly affects patients' quality of life, causing itching, skin pain, and sleep disturbances; ruxolitinib cream has shown effectiveness in treating these symptoms in adults and adolescents through two phase III clinical trials.
- In the TRuE-AD studies, patients applied different strengths of ruxolitinib cream or a vehicle cream, with results indicating that those using ruxolitinib experienced quick relief from symptoms like skin pain and sleep issues within hours or weeks of application.
- Analysis of patient-reported outcomes revealed notable improvements in overall quality of life and symptom burden after two weeks of using ruxolitinib cream compared to the vehicle, with sustained benefits observed throughout the study periods.
Article Synopsis
- Hidradenitis suppurativa (HS) can greatly impact patients' quality of life due to its association with psychological issues like anxiety and depression, often intensified by stigmatization related to physical appearance.
- A study involving 135 HS patients from 22 dermatology clinics in Europe found significant levels of perceived stigmatization, which correlated with disease duration, itchiness, and depression symptoms.
- The research emphasizes the need for comprehensive management of HS, including addressing psychological well-being and access to mental health support for better patient outcomes.
A case of idiopathic granulomatous mastitis successfully treated with certolizumab.
Ann Dermatol Venereol
December 2024
Article Synopsis
- * The article highlights the significance of incorporating mind-body therapies (MBT) in treating AD, including techniques like meditation, cognitive behavioral therapy, and mindfulness.
- * Although research is limited, a holistic approach combining MBT and traditional treatments may enhance symptom management and psychological health, especially by breaking the itch-scratch cycle.
Article Synopsis
- Dysmorphic concern is when someone worries a lot about imperfections in their looks, and this can be linked to body dysmorphic disorder (BDD).
- A study looked at how men and women with skin conditions feel about their appearance and found that women generally had more concerns than men.
- About 10.5% of patients showed signs of having BDD, with stress and feeling judged affecting both men and women, especially those with more serious skin issues.
Chronic pruritus (CP) is defined as an unpleasant sensation causing a desire to scratch and lasting > 6 weeks. It has a multifactorial etiology but is more frequently associated with chronic inflammatory dermatoses and systemic disorders. Psychogenic pruritus and neurological disorders are other less common etiologies, while, in some patients, it is idiopathic.
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- - A global study conducted from January to April 2023 assessed pruritus (itching) prevalence among 50,552 individuals across 20 countries, revealing an overall prevalence of 39.8%.
- - The study found that older adults (65+) had the highest prevalence at 43.3%, with women experiencing pruritus more frequently (40.7%) than men (38.9%).
- - Geographic differences showed higher pruritus rates in Africa (45.7%) compared to North America (41.2%) and lower rates in Europe (35.9%) and Australia (38.4%), with no notable ethnic differences in prevalence.
Article Synopsis
- The study explores the effectiveness of one-on-one, nurse-led therapeutic patient education (TPE) for children with moderate-to-severe atopic dermatitis (AD), pitting it against standard care alone.
- A total of 176 children participated, but by week 24, there was no significant difference in disease control (measured by the SCORAD index) between the two groups.
- The only notable improvement from the TPE was a reduction in fear of using topical steroids, although the intervention group displayed consistently lower disease severity throughout the study.
EADV Task Force Pruritus White Paper on chronic pruritus and chronic prurigo: Current challenges and future solutions.
J Eur Acad Dermatol Venereol
September 2024
Chronic pruritus (CP) is frequent in general medicine and the most common complaint in general dermatology. The prevalence of CP is expected to rise in the future due to the ageing population. The clinical presentation, underlying aetiology and treatment strategy of CP are heterogeneous.
View Article and Find Full Text PDFChronic nodular prurigo: Association between comorbidities, itch and quality of life.
J Eur Acad Dermatol Venereol
November 2024
Comparison of the burden of pruritus and pain: Analysis of survey data from 4018 subjects.
J Eur Acad Dermatol Venereol
November 2024
Background: Itch as the most common symptom in dermatology has been shown to be related to psychological factors such as stress, anxiety and depression. Moreover, associations were found between perceived stigmatization and itch. However, studies investigating the differences between patients with dermatoses with and without itch regarding perceived stress, stigmatization, anxiety and depression are missing.
View Article and Find Full Text PDFAlexithymia and dissociation in psychogenic pruritus: Clinical relevance and therapeutic implications.
J Eur Acad Dermatol Venereol
September 2024
Chronic kidney disease-associated pruritus (CKD-aP) is a disabling symptom which is frequent and often underestimated. Pa-MRC has a negative impact on quality of life, and is frequently accompanied by sleep disorders and depression. The approval of difelikefalin – a kappa opioid receptor agonist – in this indication requires updated recommendations.
View Article and Find Full Text PDFThe effects of air pollution on health are gaining increasing research interest with limited data on skin alterations available. It was suggested that air pollution is a trigger factor for sensitive skin (SS). However, this data was based on surveys with a lack of experimental data.
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