Quality indicators of stroke care in Colombia based on the RES-Q registry.

Objectives: This study seeks to outline the epidemiological patterns and quality of care indicators of ischemic stroke in Colombia. It serves as a pioneering effort, offering crucial national-level insights to inform evidence-based stroke policies in Colombia.

Materials And Methods: Using data from the Registry of Stroke Care-Quality (RES-Q) spanning the years 2017 to 2021, a multicenter descriptive study was conducted in Colombia.

Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption.

Background: Breast Cancer (BC) is the most common type of cancer in women around the world and 70% of cases are hormone-receptor positive (HR+). In 40% of cases, a key mechanism of endocrine resistance to the standard first line is a mutation of the ligand-binding domain (LBD) of Estrogen Receptor 1 (ESR1) encoding estrogen receptor α (ER). Most common ESR1 mutations that occur at positions 537 and 538 have been associated with poor clinical outcomes.

Combatting pesticide pollution: using liquid scintillation spectrometry to assess C-labeled hexachlorobenzene removal by mangrove Bacillus spp.

This study explored the ability of two Bacillus species isolated from mangrove sediments to degrade hexachlorobenzene (HCB), a persistent organic pollutant that affects the quality of surface water, groundwater, and soil. Hence, we analyzed bacterial growth in a medium with hexachlorobenzene as the sole carbon source. Moreover, chemical oxygen demand removal, ecotoxicity, and measured radiolabeled HCB degradation were assessed.

The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach.

Essential oils (EO) are known for their antibacterial and anti-inflammatory properties and can be used as an alternative to reduce the reliance on antimicrobials in dairy cattle. While many studies have explored the beneficial properties of EO in vitro, their effects on milk quality and milk microbiota, when applied directly to the udder skin, remain relatively unknown. This study aimed to investigate the impact of Thymus capitatus essential oil (TCEO), known for its high antibacterial and antioxidant properties, on milk microbiota using 16S rRNA sequencing, the lipidomic profile via liquid chromatography-quadrupole time-of-flight mass spectrometry, udder skin microbiota, and inflammatory biomarkers of dairy cows at the end of lactation.

Assessing barriers to meditation in patients with substance use disorder.

Background And Purpose: Individuals living with substance use disorder (SUD) often face unique challenges that can hinder their engagement in beneficial practices like meditation, which has been shown to support recovery and well-being. This study aimed to explore the perceived barriers to meditation with SUD, identify key obstacles, and inform future interventions that promote the adoption of a personal practice.

Materials And Methods: We conducted a cross-sectional analytic study with a convenience sample of participants attending a treatment center for SUD.

Pathogenic and periodontal bacteria may contribute to the fatal outcome of critically ill elderly COVID-19 patients.

Some studies suggest that the respiratory microbiome of COVID-19 patients differs from that of healthy individuals, infected patients may have reduced diversity and increased levels of opportunistic bacteria, however, the role of the microbiome in fatal SARS-CoV-2 infection remains poorly understood. Our study aimed to determine whether there are differences in the respiratory microbiome between patients who recovered from COVID-19 and those who died, by characterizing the bacterial communities of both groups. A total of 24 patients who recovered from COVID-19 and 24 who died were included in the study, patient data were analyzed for signs, symptoms and clinical variables.

Abiotrophia defectiva endocarditis implicated in antineutrophil cytoplasmic antibody-negative glomerulonephritis.

We report a rare case of antineutrophil cytoplasmic antibody (ANCA)-negative pauci-immune necrotising glomerulonephritis (PING) in () endocarditis. A woman in her 50s presented to the hospital with acute kidney injury (AKI), pancytopenia, microscopic haematuria, proteinuria and maculopapular rash. She had sepsis and endocarditis.

Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer's disease patients with mild cognitive impairment.

Objectives: Alzheimer's disease patients with mild cognitive impairment (ADMCI) show abnormal resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms (8-12 Hz) and may suffer from daytime sleepiness. Our exploratory study tested the hypothesis that they may present characteristic EEG rhythms from quiet wakefulness to light sleep during diurnal recordings.

Methods: Datasets of 34 ADMCI and 22 matched healthy elderly (Nold) subjects were obtained from international archives.

First Identification of Excited States in ^{78}Zr and Implications for Isospin Nonconserving Forces in Nuclei.

At a fundamental level, the interactions between protons and protons, protons and neutrons, and neutrons and neutrons are not identical. Such isospin nonconserving interactions emerge when comparing the excitation energy of analog states in T=1 triplet nuclei. Here, we extend such an analysis to the A=78, T=1 triplet system-the heaviest system for which such complete data exists-and find strong disagreement with contemporary theory.

Probing Strangeness Hadronization with Event-by-Event Production of Multistrange Hadrons.

This Letter presents the first measurement of event-by-event fluctuations of the net number (difference between the particle and antiparticle multiplicities) of multistrange hadrons Ξ^{-} and Ξ[over ¯]^{+} and its correlation with the net-kaon number using the data collected by the ALICE Collaboration in pp, p-Pb, and Pb-Pb collisions at a center-of-mass energy per nucleon pair sqrt[s_{NN}]=5.02  TeV. The statistical hadronization model with a correlation over three units of rapidity between hadrons having the same and opposite strangeness content successfully describes the results.

Molecular Simulation of CO/CH Transport and Separation in Polystyrene--poly(ethylene oxide)/Ionic Liquid (IL) Membranes: Insights into Nanoconfined IL Effects.

The phenomenon of ionic liquid (IL) nanoconfinement within a copolymer/IL membrane reportedly enhances membrane selectivity, solubility, and transport in gas separations. Also, the copolymer/IL membrane morphology has been found to affect IL stability at high transmembrane pressures. In this work, a combined mesoscopic dynamics simulation and hybrid grand canonical Monte Carlo/molecular dynamics (GCMC-MD) simulations were carried out to investigate the morphologies, as well as CO/CH gas diffusivities, solubilities, and selectivities of polystyrene--poly(ethylene oxide) (PS--PEO)/1-Ethyl-3-methylimidazolium thiocyanate ([EMIM][SCN]) and PS--PEO/1-Ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][TfN]) membranes.

Influence of day and night temperature and carbon dioxide concentration on growth, yield, and quality of green butterhead and red oakleaf lettuce.

Production of lettuce (Lactuca sativa) within vertical farms is an expanding segment of controlled environment agriculture-precise manipulation of environmental parameters including mean daily temperature (MDT) and carbon dioxide (CO2) concentration enables year-round production, alongside color, yield, and crop size regulation. Our objectives included 1) quantify how MDT and CO2 interact to influence lettuce growth, development, and quality; 2) model lettuce growth under several MDTs and CO2 concentrations. Green butterhead 'Rex' and red oakleaf 'Rouxaï RZ' seedlings were transplanted into hydroponic tanks under a photosynthetic photon flux density of 300 μmol·m‒2·s‒1 for 17-h·d‒1.

Hypothalamic GHRH.

Despite initial discovery in pancreatic tumors, GHRH is a 44-amino acid peptide primarily expressed in the hypothalamus. Recent RNA sequencing clarifies GHRH expression: predominantly hypothalamic in humans, with some basal ganglia presence, while extending to additional central nervous system (CNS) regions in other species. GHRH binds to its G-protein coupled receptor (GHRHR) in the arcuate (ARC), ventromedial (VMH), and periventricular (PeN) nuclei of the hypothalamus to exert its effects.

Scope and Limitations of the Use of Methanesulfonic Acid (MSA) as a Green Acid for Global Deprotection in Solid-Phase Peptide Synthesis.

N,N-dimethylformamide (DMF) and trifluoroacetic acid (TFA) are the two solvents/reagents most widely used in solid-phase peptide synthesis (SPPS). While DMF is already regulated in Europe, TFA - a member of the polyfluoroalkyl substances (PFAS) family - is expected to face similar restrictions soon. These compounds break down slowly and pose risks to human health and the environment.

Evidence Based Recommendations in Sinonasal Tumors Involving Orbit: Preservation or Exenteration? An IHNSG Guidelines.

Sinonasal tumors with orbital involvement present significant management challenges due to the complex anatomy of the orbital and sinonasal complex and the potential for severe tumor- and treatment-related morbidities. This comprehensive review examines evidence-based decision-making guidelines in the context of treating sinonasal malignancies involving the orbit. We evaluate pre-treatment assessment strategies, discuss the indications for orbital preservation versus its exenteration, explore the role of neo-adjuvant therapies, and analyze reconstruction techniques with ensuing rehabilitation approaches and quality of life.

Lifestyle modification program (IM Healthy) for cancer survivors: Implementation of a reimbursable telehealth group program during the COVID-19 pandemic.

Purpose: We designed and pilot-tested a reimbursable lifestyle change program delivered via telehealth that was initiated during the COVID-19 pandemic.

Methods: The program (IM Healthy) focused on increasing physical activity, improving nutrition, and facilitating stress management and healthy behavior change. Retrospective chart review was used to collect data on IM Healthy participants from the period of Sept 2021 to Aug 2022.

Perspectives of Hispanic and Latinx Community Members on AI-Enabled mHealth Tools: Qualitative Focus Group Study.

Background: Mobile health (mHealth) tools have the potential to reduce the burden of chronic conditions that disproportionately affect Hispanic and Latinx communities; however, digital divides in the access to and use of health technology suggest that mHealth has the potential to exacerbate, rather than reduce, these disparities.

Objective: A key step toward developing health technology that is accessible and usable is to understand community member perspectives and needs so that technology is culturally relevant and appropriately contextualized. In this study, we aimed to examine the perspectives of Hispanic and Latinx community members in Washington State about mHealth.

Digital Bowen disease: a case report and systematic review.

Digital Bowen disease (BD) is a rare type of squamous cell carcinoma in situ that affects the digits or nails. The aim of this review is to provide a comprehensive approach for the diagnosis and management of digital BD, which includes the use of reflectance confocal microscopy (RCM) as a diagnostic tool for non-glabrous skin. A literature search was conducted using the PubMed/Medline database from inception up to December 2023.

Evaluating the fidelity of AI-generated information on long-acting reversible contraceptive methods.

Introduction: Artificial intelligence (AI) has many applications in health care. Popular AI chatbots, such as ChatGPT, have the potential to make complex health topics more accessible to the general public. The study aims to assess the accuracy of current long-acting reversible contraception information provided by ChatGPT.

Preservation of cellular structure via immersion fixation in brain banking.

Immersing the brain in a solution containing formaldehyde is a commonly used method for preserving the structure of human brain tissue in brain banking. However, there are questions about the quality of preservation using this method, as formaldehyde takes a relatively long period of time to penetrate a large organ such as the human brain. As a result, there is a critical need to determine whether immersion fixation is an adequate initial preservation method.

Can attention-deficit/hyperactivity disorder be considered a form of cerebellar dysfunction?

Attention-deficit/hyperactivity disorder (ADHD) is a heterogenous disorder, commonly described for presenting difficulties in sustained attention, response inhibition, and organizing goal-oriented behaviors. However, along with its traditionally described executive dysfunction, more than half of the children diagnosed with ADHD have been reported to show difficulties with gross and fine motor skills, albeit motor impairments in ADHD continue to be a neglected area of clinical attention. The rapidly growing field of the clinical cognitive neuroscience of the cerebellum has begun to relate cerebro-cerebellar circuits to neurodevelopmental disorders.

First detection and molecular characterization of Jingmen tick virus with a high occurrence in Rhipicephalus (Boophilus) microplus collected from livestock in Cameroon (2024).

Background: Jingmen tick virus (JMTV) is a novel tick-borne virus detected for the first time in Rhipicephalus (Boophilus) microplus in China. To date, there is no information regarding the circulation of JMTV in ticks collected from livestock in Cameroon. As part of the surveillance for arboviral circulation, this study aimed to assess the presence of JMTV in ticks collected from livestock (cattle and sheep) in an area of the Akonolinga health district, Center Region, Cameroon.