Involvement of Annexin A2 in Serum-MAF Dependent Phagocytic Activation of Macrophages.

Background/aim: Serum-derived macrophage activating factor (serum-MAF) is expected to have adjuvant effects through rapid phagocytic activation, which depends on F-actin accumulation in multi-layered membrane ruffles induced within 5 min after serum-MAF addition. This study aimed to elucidate the importance of annexin A2, which is a multifunctional Ca-binding protein related to cytoskeletal membrane dynamics, in serum-MAF signalling.

Materials And Methods: Annexin A2 and F-actin localizations were analyzed via immunostaining and confocal microscopy.