Publications by authors named "Misaki T"

A 63-year-old Japanese housewife was admitted to our hospital because of hematuria and proteinuria lasting for 3 months. At the age of 59 years, she was diagnosed with neurosarcoidosis at another hospital, and she received oral glucocorticoid therapy for 1 year. Her serum angiotensin-converting enzyme (ACE) and 1, 25-dihydroxyvitamin D levels were elevated.

View Article and Find Full Text PDF
Article Synopsis
  • Red complex bacteria are highly virulent in periodontal disease, and this study focused on their relationships with other oral bacteria in older Japanese individuals.
  • Polymerase chain reaction was used to analyze dental plaque from 116 subjects, finding that individuals positive for red complex bacteria had significantly higher detection rates of certain periodontal pathogens compared to those who were negative.
  • The findings indicate that individuals harboring all three red complex species have a unique oral microbiome, showcasing greater α-diversity and lower β-diversity, suggesting they may be more prone to developing periodontal disease.
View Article and Find Full Text PDF

IgA nephropathy (IgAN), the most common primary glomerulonephritis, is considered an intractable disease with unknown pathogenic factors. In our previous study, Streptococcus mutans, the major causative bacteria of dental caries, which expresses Cnm, was related to the induction of IgAN-like nephritis. In the present study, the Cnm-positive S.

View Article and Find Full Text PDF

Background: With the decreasing age threshold for patients undergoing total hip arthroplasty (THA), there is an escalating demand for enhanced polyethylene durability. Although reports assessing wear in remelted highly cross-linked polyethylene (HXLPE) through radiographic imaging exist, a consensus regarding its oxidation level is lacking. This study investigated the wear, oxidation levels, and degradation of remelted HXLPE that was retrieved at least 10 years after THA.

View Article and Find Full Text PDF
Article Synopsis
  • The non-Bornian solvation model was applied to calculate the Gibbs energy changes for the adsorption and desorption of 14 anionic, 9 cationic, and 19 non-ionic surfactants at the oil-water interface.
  • Most surfactants, except for some non-ionic ones with specific hydrophobic groups, displayed a distinct energy minimum, allowing for accurate Gibbs energy values during their movement from bulk phases to the interface.
  • Additionally, the study revealed a linear relationship between the critical micelle concentration (CMC) of surfactants, particularly ionic ones, and two independent variables related to their properties.
View Article and Find Full Text PDF

Background: The authors describe a rare case of acute large-vessel occlusion due to an infected thrombus formation that was induced by invasive sphenoid sinus aspergillosis.

Observations: An 82-year-old man with a history of immunoglobulin G4-related disease and long-term use of steroids and immunosuppressants was admitted to the authors' hospital with severe right hemiparesis. Cerebral angiography revealed occlusion of the left internal carotid artery (ICA).

View Article and Find Full Text PDF

The authors present a patient with carotid dissection in a tortuous arterial segment who successfully underwent carotid artery stenting (CAS) by straightening the tortuosity using an inflated balloon guiding catheter (BGC) and a stent retriever (SR). A 56-year-old man was transferred to our institute with right hemiparesis and a National Institutes of Health Stroke Scale score of 9. Magnetic resonance imaging showed left internal carotid artery (ICA) occlusion and ischemic change in the parietal lobe.

View Article and Find Full Text PDF

Introduction: Osteopetrosis is a rare heritable disorder characterized by increased bone density resulting from osteoclast dysfunction. Major complications include bone fracture, osteomyelitis, anemia, and cranial nerve compression. Optic atrophy can occur due to compression of the optic nerve.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the link between the bacterial pathogen Porphyromonas gingivalis and the development of IgA nephropathy (IgAN) in patients, particularly focusing on the role of galactose-deficient IgA1 (Gd-IgA1).
  • Saliva samples from IgAN patients showed higher levels of Gd-IgA1 compared to chronic kidney disease (CKD) patients, indicating a potential connection to P. gingivalis presence.
  • IgAN patients with detectable P. gingivalis also exhibited significantly increased Gd-IgA1 and protein levels in urine, and more severe kidney damage as evident from renal biopsy findings, suggesting that P. gingivalis may contribute to IgAN
View Article and Find Full Text PDF
Article Synopsis
  • Immune checkpoint inhibitors can rejuvenate helper T-cells, which may lead to autoimmune disease-like conditions, including drug-induced arthritis.
  • The specific diagnostic process for this type of arthritis remains unclear, and this study evaluates the effectiveness of 99m Tc-MDP bone scintigraphy in diagnosing nivolumab-induced inflammatory arthritis.
  • A case study of a 67-year-old man with cancer showed joint pain and swelling after nivolumab treatment, and the diagnosis was confirmed through clinical symptoms and the imaging results indicating joint inflammation.
View Article and Find Full Text PDF

Urgent carotid artery stenting (CAS) is effective for treatment-resistant cervical internal carotid artery dissection (CICAD). We experienced a 37-year-old woman who presented with sudden onset of cervical pain, blurred vision in the right eye, and numbness in the left upper and lower extremities. Due to neurological deterioration resulting from hemodynamic impairment, urgent CAS was performed under general anesthesia.

View Article and Find Full Text PDF

Background: Thrombosed intracranial aneurysms can lead to large vessel occlusion as a result of spontaneous thrombosis. Although mechanical thrombectomy is likely effective, recurrent thromboembolism can occur if the thrombotic source remains untreated. The authors describe a case of recurrent vertebrobasilar artery occlusion due to thrombus migration from a large thrombosed vertebral artery (VA) aneurysm that was successfully treated with mechanical thrombectomy followed by stenting.

View Article and Find Full Text PDF

The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S.

View Article and Find Full Text PDF

Periodontopathic bacteria cause an inflammatory disease localized in the periodontal tissue and are associated with various conditions in other body parts. The distribution of periodontopathic bacterial species in the tonsils is unknown, even though the tonsils are located close to the oral cavity, and inflammation of the tonsils causes various systemic diseases. We detected the major periodontopathic bacterial species residing in saliva and tonsil specimens from 25 subjects undergoing tonsillectomy.

View Article and Find Full Text PDF

Background: Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare monoclonal gammopathy of renal significance with dense deposits of monoclonal immunoglobulin.

Case Presentation: We report a 78-year-old Japanese male patient with mild proteinuria and lower extremity edema. Monoclonal immunoglobulin could not be identified in his serum or urine.

View Article and Find Full Text PDF

, a Gram-positive facultative anaerobic bacterium, is a major pathogen of dental caries. The protein Cnm of is involved in collagen binding, but its other biological functions are unknown. In this study, a Cnm-deficient isogenic mutant and a complementation strain were generated from a Cnm-positive strain to help determine the properties of Cnm.

View Article and Find Full Text PDF

Aneurysms of the A1 segment of the anterior cerebral artery tend to develop in combination with various vascular anomalies of the A1 segment. Arterial branches that originate from the A1 segment and perfuse cortical regions are known to be rare. In this report, we describe a 48-year-old woman who presented with a ruptured aneurysm at the origin of an anomalous cortical artery arising from the A1 segment, for which microsurgical neck clipping was performed.

View Article and Find Full Text PDF

A relationship between IgA nephropathy (IgAN) and bacterial infection has been suspected. As IgAN is a chronic disease, bacteria that could cause chronic infection in oral areas might be pathogenetic bacteria candidates. Oral bacterial species related to dental caries and periodontitis should be candidates because these bacteria are well known to be pathogenic in chronic dental disease.

View Article and Find Full Text PDF

IgA nephropathy (IgAN) has been considered to have a relationship with infection in the tonsil, because IgAN patients often manifest macro hematuria just after tonsillitis. In terms of oral-area infection, the red complex of periodontal bacteria ( (), and ) is important, but the relationship between these bacteria and IgAN remains unknown. In this study, the prevalence of the red complex of periodontal bacteria in tonsil was compared between IgAN and tonsillitis patients.

View Article and Find Full Text PDF

Members of the enhancer of split- and hairy-related protein (SHARP) family, SHARP-1 and SHARP-2, are basic helix-loop-helix transcriptional repressors and belong to the clock genes. In this study, an effect of retinoic acid (RA) on the SHARP family gene expression in the differentiated cells was examined. RA rapidly and temporarily induced the SHARP-2 mRNA expression in hepatic H4IIE cells.

View Article and Find Full Text PDF

The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S.

View Article and Find Full Text PDF

The duration of viral shedding of SARS-CoV-2 is usually less than 10 days. We experienced a COVID-19 case with prolonged viral shedding for 2 months. His cell mediated immunity has been depressed (CD4T cell <100/μl) due to advanced malignant lymphoma and chemotherapy which had been completed 4 months prior to the onset of symptoms of COVID-19.

View Article and Find Full Text PDF

A patient undergoing a bilateral sagittal split and LeFort 1 maxillary osteotomy performed under general anesthesia required emergent intraoperative exchange of a potentially damaged nasotracheal tube. This exchange was smoothly performed under constant indirect visualization using the McGrath MAC video laryngoscopy system. After the exchange, ventilation of the patient dramatically improved.

View Article and Find Full Text PDF

Background: We previously found that worse dental caries status was associated with high pulse pressure among patients on hemodialysis, indicating that such patients might have arteriosclerosis. In this study, we used abdominal computed tomography to evaluate arteriosclerosis in patients on hemodialysis and investigated the association between arteriosclerosis and dental caries status. We also prospectively examined risk factors associated with 2-year prognosis.

View Article and Find Full Text PDF