Publications by authors named "Misaki Ohashi"
Article Synopsis
- Research shows that our emotions and gut health are connected, which is seen in conditions like irritable bowel syndrome (IBS).
- Scientists studied mice that were stressed to see how it affected their gut, and this stress caused changes like faster digestion and more pain.
- A traditional medicine helped improve these gut issues in the stressed mice, suggesting that stress-related depression can lead to IBS-like symptoms without any physical damage to the gut.
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism. However, a recent study has demonstrated that disulfiram also potently inhibits the cytoplasmic protein FROUNT, a common regulator of chemokine receptor CCR2 and CCR5 signaling.
View Article and Find Full Text PDFUltrasonic vocalization (USVs) is a promising tool to measure behavioral anxiety in rodents as USV recording is noninvasive, behaviorally relevant, ethological, and reproducible. Studies reporting the effects of stress-induced USVs in adult mice remain limited and debated. We investigated the conditions under which mice emit aversive USVs and evaluated the effects of psychiatric drugs on stress-induced USVs.
View Article and Find Full Text PDFMycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).
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