Publications by authors named "Misaki Nakasone"
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan in Chinese). Aged mice fed a high-fat diet containing 2% BTS extract for 28 days exhibited a significant reduction in weight gain and accumulation of visceral and subcutaneous fat, which were greater degree of reduction than those of the young mice. When the treatment period was extended to two months, the serum aspartate aminotransferase and alanine aminotransferase levels and the accumulation of fat droplets in the hepatocytes decreased.
View Article and Find Full Text PDFArticle Synopsis
- * This study investigates the role of different types of cell death (apoptosis, necroptosis, and ferroptosis) in triggering inflammation in fatty liver, using a special diet model.
- * The findings indicate that necrosis occurs before apoptosis in NASH development, with ferroptosis being the critical type of cell death that initiates inflammation, suggesting it could be a target for future therapies.