Browse Categories

Publications by authors named "Misaki Kimura"

  • Page 1 of 1
Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons.
Fumiaki Yoshida Ryota Nagatomo Shun Utsunomiya Misaki Kimura Shiyori Shun

Transl Psychiatry

October 2024

Article Synopsis
  • * Research identified that levels of Lingo2, a protein linked to excitatory synapse formation, were increased in neurons from the VPA model, suggesting its role as an excitatory synapse organizer.
  • * The secreted form of Lingo2 (sLingo2) was found to enhance excitatory synapses in both mouse and human neurons, indicating that better understanding sLingo2's mechanisms could shed light on the development of ASD.
View Article and Find Full Text PDF
Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms.
Takafumi Yumoto Misaki Kimura Ryota Nagatomo Tsukika Sato Shun Utsunomiya

Mol Autism

September 2020

Background: Several genetic alterations, including point mutations and copy number variations in NLGN genes, have been associated with psychiatric disorders, such as autism spectrum disorder (ASD) and X-linked mental retardation (XLMR). NLGN genes encode neuroligin (NL) proteins, which are adhesion molecules that are important for proper synaptic formation and maturation. Previously, we and others found that the expression level of murine NL1 is regulated by proteolytic processing in a synaptic activity-dependent manner.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Misaki Kimura"

  • - Misaki Kimura's research primarily focuses on the molecular mechanisms underlying Autism Spectrum Disorder (ASD), particularly how specific proteins affect synaptic organization and function in neurons.
  • - In a recent study, Kimura identified that the soluble form of Lingo2 plays a crucial role as an excitatory synapse organizer, revealing new insights into the excitatory/inhibitory balance in neuronal signaling related to ASD.
  • - Kimura's earlier work examined how autism-associated mutations in neuroligin 4X disrupt synaptogenic activity, contributing to our understanding of the genetic basis for synaptic formation and its implications for ASD and other psychiatric disorders.

Privacy Policy Site Map

© LitMetric 2024. All rights reserved.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionii2fm6qqf5pfhr6q4ard0cf9ar5j3gst): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once