Association of the single nucleotide polymorphism rs1697421 with an increased postprandial serum phosphorus level.

Background: A high serum phosphorus (P) level is a risk factor for cardiovascular disease (CVD) and mortality in patients with chronic kidney disease (CKD). Moreover, increased postprandial serum P levels after high dietary P intake impair vascular endothelial function. Therefore, management of postprandial serum P levels is important in CKD patients.

Phosphatemic Index Is a Novel Evaluation Tool for Dietary Phosphorus Load: A Whole-Foods Approach.

Objective: Dietary phosphorus (P) restriction is crucial to treat hyperphosphatemia and reduce cardiovascular disease risk and mortality in patients with chronic kidney disease (CKD) and the wider population. Various methods for dietary P restriction exist, but the bioavailability of P in food should also be considered when making appropriate food choices to maintain patients' quality of life. Here, we propose the "Phosphatemic Index" (PI) as a novel tool for evaluating dietary P load based on P bioavailability; we also evaluated the effect of continuous intake of different PI foods in mixed meals on serum intact fibroblast growth factor 23 concentration.

Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study.

Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses.