A molecular modelling study of the effects of pivalate ligand substitutions on the magnetic properties of chromium-wheels host complexes.

In our recent article, we had a successful experience in applying binuclear chromium (III) model ([CrF(tBuCO)(HO)(OH)]) instead of real chromium-wheel host complex ([CrF(tBuCO)]) to calculate the effect of bridged-ligands substitution on the exchange coupling constants (J) values of the complexes. In this work our experienced procedure was used to evaluate the effect of pivalate (tBuCO) ligands substitution on the J values of the complexes. For this, at first two new groups of complexes were designed based on the replacement of pivalate by X-tBuCO and X-iPrCO anionic ligands (where X represents F, Cl, Br and I halogens) and then their J values were calculated.

Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action.

Background: Psychiatric disorders are substantially associated with reduced quality of life and increased mortality. Depression and anxiety are two of the most common psychiatric disorders that often co-occur with each other as well as with other mental health conditions. Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects.

Neuroprotective and antihyperalgesic effects of orexin-A in rats with painful diabetic neuropathy.

Aim Of Study: Diabetes mellitus is related to the development of neuronal tissue injury in different peripheral and central nervous system regions. A common complication of diabetes is painful diabetic peripheral neuropathy (PDN). We have studied the neuroprotective and anti-nociceptive properties of neuropeptide orexin-A in an animal experimental model of diabetic neuropathy.

Life expectancy of HIV-positive patients after diagnosis in Iran from 1986 to 2016: A retrospective cohort study at national and sub-national levels.

Objectives: Little is known about the life expectancy of individuals with human immunodeficiency virus (HIV) in Iran. This study therefore aimed to estimate the life expectancy of HIV-positive patients in Iran.

Methods: In this retrospective cohort study, we extracted data from the Center for Disease Control and Prevention of the Ministry of Health and Medical Education and the Death Registration System.

In silico and in vitro study of magnetic niosomes for gene delivery: The effect of ergosterol and cholesterol.

A low transfection efficiency and failure to deliver therapeutic genes to target organs limit the use of vesicular systems in gene therapy. In this study, magnetic niosomes were used to improve transfection efficiency and overcome limitations. In this light, Tween 60 and Span 60 molecules were employed as the bilayer component and ergosterol and/or cholesterol as membrane-stabilizing agents.

Surface-grafted lanthanoid complexes of the tungstosilicate polyanion [SiWO]: a synthetic, structural and computational investigation.

As an extension of our continued interest in the preparation of inorganic-organic hybrids, we report the successful hydrothermal synthesis of sodium tris[triaqua(μ-1,10-phenanthroline-2,9-dicarboxylato)dysprosium(III)] silicododecatungstate dodecahydrate, {[DyNa(CHNO)(HO)(SiWO)]·12HO} or Na[Dy(PDA)(HO)][SiWO]·12HO (1), and sodium aqua tris[tetraaqua(μ-4-hydroxypyridine-2,6-dicarboxylato)praseodymium(III)] silicododecatungstate dodecahydrate, {[NaPr(CHNO)(HO)(SiWO)]·12HO} or Na(HO)[Pr(pydc-OH)(HO)][SiWO]·12HO (2) (in which HPDA is 1,10-phenanthroline-2,9-dicarboxylic acid and Hpydc-OH is 4-hydroxypyridine-2,6-dicarboxylic acid or chelidamic acid). Both compounds have been characterized using elemental analysis, IR spectroscopy and X-ray diffraction methods. Structural characterization by single-crystal X-ray diffraction reveals that these compounds consist of [SiWO] Keggin-type polyoxometalates (POMs), where a single {WO} triad is decorated with a trinuclear Ln complex.

Years of life lost due to asthma in a population-based 10-year study in Yazd, Iran.

Introduction: Asthma is a prevalent disease in both children and adults. Significant progress in the management of asthma and prevention of asthmatic attacks resulted in a reduction of asthma deaths, but there is a variation among different regions based on health-care access and environmental factors. We aimed to investigate the trend of asthma mortality during a 10-year period in Yazd Province, a region in the center of Iran.

Effect of a Copper (II) Complex on The Induction of Apoptosis in Human Hepatocellular Carcinoma Cells.

Objectives: In the present study, we aimed to identify the anti-proliferative potential of [Cu(L)(2imi)] complex [L = 2-(((5-chloro-2-oxyphenyl)imino)methyl)phenolato) and 2imi = 2-methyl imidazole] against HepG2 cells as an in vitro model of human hepatocellular carcinoma and normal mouse fibroblast L929 cells. Methods: The cytotoxic and apoptotic effects of [Cu(L)(2imi)] complex on HepG2 cells and normal fibroblasts (L929) were examined by MTT assay and flow cytometry, respectively. Results: Cytotoxicity induced by [Cu(L)(2imi)] complex was time dependent.

Surface markers of human embryonic stem cells: a meta analysis of membrane proteomics reports.

Human embryonic stem cells (hESCs) have unique biological features and attributes that make them attractive in various areas of biomedical research. With heightened applications, there is an ever increasing need for advancement of proteome analysis. Membrane proteins are one of the most important subset of hESC proteins as they can be used as surface markers.

The Art of Validating Quantitative Proteomics Data.

Western blotting as an orthogonal validation tool for quantitative proteomics data has rapidly become a de facto requirement for publication. In this viewpoint article, the pros and cons of western blotting as a validation approach are discussed, using examples from our own published work, and how to best apply it to improve the quality of data published is outlined. Further, suggestions and guidelines for some other experimental approaches are provided, which can be used for validation of quantitative proteomics data in addition to, or in place of, western blotting.

Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection.

Glaucoma is characterized by the loss of retinal ganglion cells (RGC), and accordingly the preservation of RGCs and their axons has recently attracted significant attention to improve therapeutic outcomes in the disease. Here, we report that Src homology region 2-containing protein tyrosine phosphatase 2 (Shp2) undergoes activation in the RGCs, in animal model of glaucoma as well as in the human glaucoma tissues and that Shp2 dephosphorylates tropomyosin receptor kinase B (TrkB) receptor, leading to reduced BDNF/TrkB neuroprotective survival signaling. This was elucidated by specifically modulating Shp2 expression in the RGCs in vivo, using adeno-associated virus serotype 2 (AAV2) constructs.

Distribution and development of molecularly distinct perineuronal nets in visual thalamus.

Visual information is detected by the retina and transmitted into the brain by retinal ganglion cells. In rodents, the visual thalamus is a major recipient of retinal ganglion cells axons and is divided into three functionally distinct nuclei: the dorsal lateral geniculate nucleus (dLGN), ventral LGN (vLGN), and intergeniculate leaflet. Despite being densely innervated by retinal input, each nucleus in rodent visual thalamus possesses diverse molecular profiles which underpin their unique circuitry and cytoarchitecture.

Correlation between drinking water fluoride and TSH hormone by ANNs and ANFIS.

Background: Artificial neural networks (ANNs) and adaptive neural-fuzzy Inference system (ANFIS) are the best solutions to finding the correlation between some water parameters and human hormones. The correlation between thyroid stimulating hormone (TSH) and drinking water fluoride studied by ANN and ANFIS models in Yazd city.

Method: In this study, eighty people with thyroid gland disorder and 213 healthy people invited.

Morphological and molecular characterization of Onchocerca fasciata (Nematoda, Onchocercidae) from dromedary camels (Camelus dromedarius) in Iran.

Skin nodules of Onchocerca fasciata Railliet and Henry, 1910 (Spirurida, Onchocercidae) are a common finding in dromedary camels, though with a minimal clinical impact. There is little information about the morphology, molecular make-up and pathological impact of this parasite. Onchocerca fasciata nodules (1.

Developing a magnetic metal organic framework of copper bearing a mixed azido/butane-1,4-dicarboxylate bridge: magnetic and gas adsorption properties.

A magnetic metal organic framework {[Cu(but-1,4-dc)0.5(N3)(H2O)]·H2O}n (MFUM-1(Cu)) (but-1,4-dc = butane-1,4-dicarboxylate) was synthesized and characterized structurally and magnetically. In MFUM-1(Cu), each CuII ion has a distorted octahedral geometry with an obvious Jahn-Teller distortion, where the coordination environment is composed of mixed EO-azido/aliphatic based carboxylate/H2O threefold bridges.

Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes.

To improve the efficiency of niosomal drug delivery, here we employed two tactics. First, niosomes were magnetized using FeO@SiO mangnetic nanoparticles, and second, their surface was modified by PEGylation. PEGylation was intended for increasing the bioavailability of niosomes, and magnetization was used for rendering them capable of targeting specific tissues.

Synergistic interactions between konjac-mannan and xanthan/tragacanth gums in tomato ketchup: Physical, rheological, and textural properties.

In this research, simultaneous contribution of konjac-mannan (0.3%), xanthan (0.3%), and tragacanth (0.

Lawsone-loaded Niosome and its antitumor activity in MCF-7 breast Cancer cell line: a Nano-herbal treatment for Cancer.

Phytochemicals like Lawsone have some drawbacks that stem from their poor solubility. Low solubility in aqueous mediums results in low bioavailability, poor permeability and instability of phytochemical compounds in biological environments. The aim of this study was to design nanoniosomes containing Lawsone (Law) using non-ionic surfactants and cholesterol.

Photochemical and electrochemical hydrogen evolution reactivity of lanthanide-functionalized polyoxotungstates.

The first example of hydrogen evolution reactivity (HER) of lanthanide-functionalized Keggin-based polyoxotungstates under photochemical and electrochemical conditions is reported. The HER activity under homogeneous, visible light-driven conditions and under heterogeneous, electrochemical conditions depends on the type of lanthanide functionalization, so that a new class of model HER catalysts for systematic reactivity studies is now accessible.

Nisin Induces Cytotoxicity and Apoptosis in Human Asterocytoma Cell Line (SW1088).

Background: Nisin is a member of the group of anti-microbial peptides which are considered as bacteriocins, but it possesses a vast range of activities. Astrocytoma is among the most prevalent types of brain tumor globally. Considering all facts about this peptide, the aim of the present study was the evaluation of any impact of nisin on proliferation and apoptosis of an astrocytoma cell line (SW1088).

Linear and nonlinear analyses of femoral fractures: Computational/experimental study.

This paper describes two new methods for computational fracture analysis of human femur using Quantitative Computed Tomography (QCT) voxel-based finite element (FE) simulation. The paper also reports comprehensive mechanical testing for validation of the methods and evaluation of the required material properties. The analyses and tests were carried out on 15 human femurs under 11 different stance-type loading orientations.

The Micro-Shear Bond Strength of Various Resinous Restorative Materials to Aged Biodentine.

Introduction: The type of materials and application time of veneering restorations on calcium silicate cements are important factors which influence the interfacial properties. The aim of this study was to measure the micro-shear bond strength of a resin composite (RC) using several adhesive systems and a resin-modified glass ionomer cement (RM-GIC) to different aged Biodentine specimens.

Methods And Materials: A total of 15 Biodentine blocks were prepared and assigned to three aging periods: 12 min, one week and one month.

Double strand DNA-based determination of menadione using a FeO nanoparticle decorated reduced graphene oxide modified carbon paste electrode.

In this work an electrochemical label free DNA biosensor (ds-DNA) for the determination of menadione (MD) was developed. The biosensor was constructed using a modified nanocomposite consisting of FeO nanoparticles decorated reduced graphene oxide (Gr) on a carbon paste electrode (CPE). Scanning electron microscope (SEM), energy dispersive X-ray (EDAX) and Fourier transform infrared (FT-IR) spectroscopy confirmed the structure of the synthesized nanocomposites (electrode composition).

A novel gold nanorods-based pH-sensitive thiol-ended triblock copolymer for chemo-photothermo therapy of cancer cells.

Currently an effective strategy in nanomedicine for cancer therapy is the combination of photothermal therapy with chemotherapy. Because combination cancer therapy improve the therapy efficiency by synergistic effects and overcoming drug resistance as compared to monotherapy possesses. According to these facts, gold nanorods-cored biodegradable micelles were prepared by coating gold nanorods (AuNRs) with synthesized pH-sensitive thiol-ended amphiphilic triblock copolymer (PAA-b-PDMAEMAQ-b-PCL-SH).

Adherence of to Microhybrid and Nanohybrid Resin Composites and Dental Amalgam: An In Vitro Study.

Objectives: () is a cariogenic microorganism. The restorative materials which harbor a biofilm with high levels of can accelerate the occurrence of dental caries. The purpose of this study was to evaluate the influence of different restorative materials on colonization in a simple in-vitro biofilm formation model.