Interactions between DASH-style diet and ADIPOQ and ARL15 genes polymorphisms on blood pressure and central obesity in Iranian adults.

This study aimed to investigate the interactions between the Dietary approaches to stop hypertension (DASH) and the rs1501299 and rs6450176 SNPs in terms of cardiometabolic risk factors. This cross-sectional study was conducted on 387 adults (20-70 years old) residing in Yazd, Iran. The participants were selected from participants in the recruitment phase of the Yazd Health Study (YaHS) which is a population-based cohort of 9,962 adults.

MicroRNAs' Significance in Retinoblastoma Diagnosis and Treatment: The Little Heroes.

One in 16, 000 live births is affected by the retinal tumor RB (retinoblastoma), which is frequently found in a child's early years. Both of the RB1 alleles that have been locally mutated in the affected retina are present in 60 percent of cases. Retinoblastoma (RB) can be detected using a variety of techniques, including imaging of the brain and orbits, eye examinations under anesthesia (EUAs), and the discovery of cell-free tumor DNA in samples of aqueous humor or plasma.

Bike-Riding Training may Improve Communication Skills and Stereotyped Behavior in Adolescents With Autism.

This research aimed to establish whether 12 weeks of bicycle-riding skills exercises with massed and distributed practice frequency at low and high intensity affect communication performance and stereotyped behavior among adolescent boys with autism. Fifty autistic boys aged 13.3 ± 1.

The prevalence of herbal medicine use and related factors among diabetic patients in Tabriz, Iran, 2023: a cross-sectional study.

Objectives: This study was designed to characterize the prevalence, pattern of herbal use, and related factors among diabetic patients in Tabriz, Iran.

Methods: A descriptive cross-sectional study was carried out on 322 diabetic patients with random cluster sampling of specialized and subspecialized clinics in Tabriz, Iran. Binary logistic regression analysis was performed to evaluate the association between predictor variables (sociodemographic and disease-related characteristics and patient preference for treatment type) with herb use Interviews were conducted using a structured questionnaire from October 1, 2022, to April 23, 2023.

The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis.

Background: Older adults experience chronic inflammation, which is associated with health conditions such as sarcopenia, and resulting in reduced functional capacity. Resistance training (RT) is a beneficial intervention for improving health in the elderly.

Objective: This study aimed to investigate the effect of RT on inflammatory biomarkers, body composition, and functional capacity in healthy adults aged 60 years and over.

Prevalence of cataracts in Iran based on the Persian eye cohort study.

The PERSIAN eye cohort study is a population-based study that evaluates the overall prevalence of cataracts and their subtypes (nuclear sclerosis, cortical, and PSC) in Iran. In this study, from January 2015 to September 2021, 16,016 participants over 35 years of age from four provinces who were selected by random cluster sampling were examined. Demographic information, education, socioeconomic status, and place of residence were collected through interviews.

Screening and identification of potential target of 1'-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer.

1'-Acetoxychavicol acetate (ACA) eliminates breast cancer cells via the HER2/MAPK/ERK1/2 and PI3K/AKT pathways, and it also directly influences endocrine resistance by both enhancing pro-apoptotic signals and suppressing pro-survival molecules. This study utilized bioinformatics to assess ACA target genes for lapatinib-resistant breast cancer. We identified differentially expressed genes (DEGs) using GSE16179 microarray data.

The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control study.

Background: Ulcerative colitis is a form of chronic inflammatory bowel disease (IBD) marked by ongoing inflammation of the mucosal lining that extends from the rectum to the upper part of the colon. Vitamin D regulates immune responses in several autoimmune and inflammatory diseases, including ulcerative colitis. Therefore, the study aims to investigate the role of vitamin D in the pathogenesis and treatment of ulcerative colitis.

Optimization of Selection Agent Concentrations and Expanding G418 Utility for Gentamicin Resistance in Marchantia polymorpha.

Genetic transformation of plants is pivotal for advancing biotechnology, with success depending largely on effective selection methods. has emerged as a model plant due to its evolutionary importance, ease of manipulation, and simple genetic structure. However, inconsistent antibiotic performance and limited studies on optimal selection agent concentrations have posed challenges.

Comparison of Gene Polymorphisms of ACE1 and ACE2 and the Level of Total ACE Activity in the Blood of Afghans and Iranians with COVID-19 and Its Relationship with Disease Severity.

Field evidence indicates differences in the rate and severity of COVID-19 infection among Afghans and Iranians, potentially influenced by individual genomic variances. Therefore, investigating the potential causes of these disparities holds significant clinical importance. This study aims to explore and compare variations in the genes encoding angiotensin-converting enzyme 1 (ACE1) and angiotensin-converting enzyme 2 (ACE2), along with total ACE activity levels in the blood of Afghans and Iranians with COVID-19, to assess any potential correlation with disease severity.

Investigating the interaction between major dietary patterns and psychological disorders in association with sleep quality and quantity among Iranian adults: YaHS-TAMYZ study.

Objectives: The aim of the present study was to investigate if major dietary patterns (DPs) interact with psychological disorders (PDs) in association with sleep quality and quantity among a large sample of Iranian adults living in Yazd, Iran.

Methods: This cross-sectional investigation was conducted on the baseline data of a population-based Iranian cohort study (Yazd Health Study-Taghzieh Mardom-e-YaZd: YaHS-TAMYZ). All data regarding dietary intakes, PDs, and sleep status were collected via validated questionnaires.

Comparing the effect of stretching and compression exercises on flexion relaxation ratio of back muscles in patients having deep gluteal syndrome: A randomized trial.

Background: Different treatments have been proposed for patients with deep gluteal syndrome (DGS). Stretching and compression exercises are commonly used to treat DGS.

Objective: To compare the effects of compression or stretching exercises on the flexion-relaxation response (electromyography signals of back muscles) in patients with DGS.

A randomized clinical trial evaluating Hydralazine's efficacy in early-stage Alzheimer's disease: The EHSAN Study.

Alzheimer's Disease (AD), a neurodegenerative disorder escalating worldwide, remains incurable with existing interventions merely mitigating symptoms. Hydralazine, an antihypertensive agent, has displayed neuroprotective potential in AD animal models via amplification of mitochondrial functionality and stimulation of stress management and repair pathways. Nevertheless, its effectiveness and tolerability in human AD cohorts are yet to be confirmed.

Association between chronic kidney disease and cardiovascular disease risk factors in elderly: results from the first phase of Fasa and Shahedieh cohort studies.

Background: Chronic kidney disease (CKD) is associated with increased cardiovascular disease (CVD) risk factors and morbidity in the elderly population. This study aimed to examine the association between CKD and CVD risk factors in the elderly population of Fasa and Yazd (Shahdieh), Iran, using the data from the enrolment phase of Fasa and Shahedieh cohort studies.

Methods: We conducted a cross-sectional analytical study using data from Fasa and Shahedieh cohort studies, which enrolled 1487 and 1507 participants aged over 60 years, respectively.

Integrated proteome and metabolome analysis of the penultimate internodes revealing remobilization efficiency in contrasting barley genotypes under water stress.

The remobilization of stored assimilates from stems to seeds plays a pivotal role in augmenting barley yield, particularly under water stress conditions. This study examines the molecular mechanisms underlying stem reserve utilization by conducting a comparative analysis of the proteome and metabolome across three barley contrasting genotypes: Yousef, Morocco, and PBYT17. Evaluations were performed at 21 and 28 days after anthesis (DAA) under both water stress and control conditions.

Lipid variability in drug-naïve individuals affected with Major Depressive Disorder: a systematic review and meta-analysis.

Background: This study aimed to provide a comprehensive synthesis of the evidence examining lipid profiles in drug-naïve MDD patients.

Materials And Methods: We searched PubMed, Scopus, and ISI Web of Science up to August 2023 for total cholesterol, HDL-C, LDL-C, and triglyceride levels in drug-naïve MDD patients.

Results: A total of 17 articles comprising 2174 individuals including drug-naïve MDD subjects and controls were included.

Dual molecular tweezers extending from a nanohoop.

The field of nanohoops is mature enough that synthetic protocols exists to tune their size, composition (incorporation of heteroaromatic building blocks), connectivity ( linkages), and solubility in different media (hydrophobic hydrophilic). Here, we report an additional dimension incorporating the concept of fullerene tweezers into a nanohoop. The resulting hybrid nanohoop is highly strained at 77 kcal mol, possesses a quantum yield of 0.

Nonlinear mechanical response of finite-length soft composites with random dislocations.

The effects of random dislocations on the vibrational properties of finite-length RNA and DNA macro-structures have been investigated by means of a harmonic Hamiltonian and the Green's function method. The RNA molecule has been modeled using a half ladder model, and three models (a fishbone model and two different strand models) have been employed to model the structure of DNA. The lengths of the finite and cyclic systems are gradually increased to more accurately approximate the structures of RNA and DNA.

The association between adherence to unhealthy plant-based diet and risk of COVID-19: a cross-sectional study.

Background: The fast spread of the coronavirus disease 2019 (COVID-19) epidemic and its high mortality were quickly considered by the health community. Dietary patterns play an important role in strengthening or weakening the immune system and thus incidence of diseases.

Aim: The present study can provide a comprehensive picture of the association between adherence to unhealthy plant-based diet (uPDI) and COVID-19 incidence.

Growth Performance and Microbial Activity Positively Responded to Interactive Effect of Nitrogen and Phosphorus in Young Holstein Dairy Calves.

We hypothesized that nitrogen (N) and phosphorus (P), as two pivotal nutrients that contributed to the growth of growing animals, may have interactive effect on growth performance and microbial development in young calves. For this purpose, feeding two starter protein contents (20% [20CP] vs. 24% [24CP], DM basis) and two phosphorus supplementation levels (0.

Prevalence, Incidence, and Risk Factors of Hypothyroidism in Adult Residents of Yazd Greater Area, 2015-2021: Results of Yazd Health Study.

Background: Any abnormal change in thyroid hormone levels leads to thyroid disorders, including hyperthyroidism, hypothyroidism, goiter, and so on. Recent studies have reported an increasing prevalence and incidence of thyroid disorders worldwide. This study aims to determine the hypothyroid prevalence, incidence, and risk factors related to this disorder.

Evaluation of the immunomodulatory activity of probiotics mixture and sulfasalazine against acetic acid-induced colitis in a murine model.

Background: Currently, the use of probiotics to treat inflammatory bowel diseases (IBD) is widely accepted because of their gut microbiota modulation capabilities and anti-inflammatory potential.

Objective: The aim of this study is to examine the immunomodulatory outcomes of probiotics and sulfasalazine in the acetic acid-induced colitis murine model.

Methods: The animals were randomly assigned to one of the seven groups.

Patients' reasons for consulting a general practitioner at the time of having dental problems: a qualitative study.

Introduction: Many patients consult general practitioners instead of dentists for their oral and dental problems every year. This study aims to find the reasons why patients consult general practitioners when they have dental problems.

Methods: The sample consisted of patients visiting dentists and general practitioners in Kerman, Iran.

Self-management education for hypertension, diabetes, and dyslipidemia as major risk factors for cardiovascular disease: Insights from stakeholders' experiences and expectations.

Background: Cardiovascular disease (CVD) is a leading cause of premature death, with hypertension, diabetes, and dyslipidemia as major risk factors. Effective self-management (SM) is crucial for controlling these conditions and improving quality of life. This study examines stakeholders' experiences and expectations of SM education to enhance program development.

Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer.

The present investigation aimed to develop niosomes containing gold nanoparticles (Nio-AuNPs) and to evaluate the combinational effect of Nio-AuNPs and x-ray radiation therapy (XRT) on growth inhibition potential and induction of apoptosis in the A549 cell line. Gold nanoparticles (AuNPs) were synthesized, and niosomes were prepared using the thin-film hydration method. Various techniques were employed to determine their physiochemical characteristics.