Publications by authors named "Mirtha Grande"
Article Synopsis
- The study investigated the prevalence of gestational diabetes mellitus (GDM) and its risk factors in a sample of 1300 pregnant women in Lima, Peru, revealing a GDM prevalence of approximately 16%.
- Key risk factors identified included maternal obesity (24.4%), family history of diabetes, and antepartum depression (10.6%), with obesity showing a significant association with GDM.
- The findings suggest the need for targeted intervention programs that focus on early diagnosis and management of GDM, considering these identified risk factors among pregnant women.
Background: Obstructive sleep apnea (OSA), a common and serious disorder in which breathing repeatedly stops during sleep, is associated with excess weight and obesity. Little is known about the co-occurrence of OSA among pregnant women from low and middle-income countries.
Methods: We examined the extent to which maternal pre-pregnancy overweight or obesity status are associated with high risk for OSA, poor sleep quality, and excessive daytime sleepiness in 1032 pregnant women in Lima, Peru.
The deposition of the Alzheimer amyloid beta-peptide (Abeta) fibrils in brain is a key step in Alzheimer's disease. The aggregated Abeta is found to be toxic to neurons since cells die when the aggregated Abeta is added to the cell culture medium. However, target of action of Abeta to cells is unknown.
View Article and Find Full Text PDFObjective: We have previously developed methods for the quantification of different macromolecules in aspiration biopsy material and described the changes in prostate-specific antigen (T-PSA) during cancer treatment. We have now studied the changes in tissue prostatic acidic phosphatase (T-PAP) in 58 endocrine-treated patients with prostatic carcinoma and compared these data with cancer development data and tissue PSA (T-PSA) levels.
Material And Methods: PAP and PSA were quantified in aspiration biopsies taken before treatment and after 6 and 12 months of treatment.
Objective: To study effects of estrogens on endothelin-1 (ET-1) mRNA expression in the androgen-sensitive LNCaP-FGC cell line and its androgen-resistant derivative LNCaP-r. Further, if effects of estrone sulfate (E1S) are mediated via conversion to estradiol-17beta (E2). Estrogens have been shown to down-regulate ET-1, a mediator of the osteoblastic response of bone to metastatic prostate cancer.
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