Water-Polymer Slide Electrification in Polyethylene Films Coated with Amphiphilic Compounds and Its Connection to Surface Properties Dependent on Water-Polymer Interactions.

Slide electrification experiments were performed on low-density polyethylene films () and sprayed with five amphiphilic compounds, including antistatic and slip additives. Drops of aqueous solutions were delivered on the films and after sliding spontaneously acquired a net electrical charge (), which is dependent on the pH and ionic strength. The slide electrification was detected in pristine films and those with five additives.

Modified ribavirin analogues as antiviral agents against Junín virus.

In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever.

Increased Surface Roughness in Polydimethylsiloxane Films by Physical and Chemical Methods.

Two methods, the first physical and the other chemical, were investigated to modify the surface roughness of polydimethylsiloxane (PDMS) films. The physical method consisted of dispersing multi-walled carbon nanotubes (MWCNTs) and magnetic cobalt ferrites (CoFe₂O₄) prior to thermal cross-linking, and curing the composite system in the presence of a uniform magnetic field . The chemical method was based on exposing the films to bromine vapours and then UV-irradiating.

Synthesis and in vitro antiproliferative activities of (5-aryl-1,2,4-oxadiazole-3-yl) methyl d-ribofuranosides.

The emergence of multidrug resistance cell lines is one of the major obstacles in the success of cancer chemotherapeutic treatment. Therefore, it remains a big challenge the development of new and effective drugs to defeat cancer. The presence of nitrogen heterocycles in the architectural design of drugs has led to the discovery of new leading compounds.

Improving bone cement toughness and contrast agent confinement by using acrylic branched polymers.

A new biomedical material to be used as part of acrylic bone cement formulations is described. This new material is tough, its Young's Modulus is similar to the one of poly (methylmethacrylate) and the contrast agent, usually employed in acrylic bone cements, is homogeneously distributed among the polymeric matrix. Additionally, its wear coefficient is 66% lower than the one measured in poly(methyl methacrylate).

Acrylic bone cements: the role of nanotechnology in improving osteointegration and tunable mechanical properties.

Nanotechnology is an extremely powerful emerging technology, which is expected to have a substantial impact on biomedical technology, especially in tissue engineering and drug delivery. The use of nanocompounds and nanoparticles in the synthesis of improved bone cements to be applied in vertebroplasty/kyphoplasty and arthroplasty, is of great interest due to the increasing incidence of osteoporosis and osteoarthritis. This review reports new advances in the development of acrylic bone cements, using different radio-opalescent nanomaterials taking into consideration their influence on the mechanical behavior and biocompatibility of the resulting acrylic bone cement.

Antiviral activity of an N-allyl acridone against dengue virus.

Background: Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or prevention. In a previous screening assay, we identified a group of N-allyl acridones as effective virus inhibitors.

1,2,4-Triazole D-ribose derivatives: design, synthesis and antitumoral evaluation.

Herein we report the design, synthesis and characterization of novel 1,2,4-triazole d-ribose derivatives, as well as their synthetic precursors. The antitumoral activity against T cell lymphoma cell line of these products was studied. Structures containing a 1,2,4-triazolic ring linked by sulfur to the carbohydrate moiety showed a moderate antiproliferative activity.

Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative.

There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective antiviral activity against the HF causing arenavirus Junin virus (JUNV) of the compound 10-allyl-6-chloro-4-methoxy-9(10H)-acridone, designated 3f. The effectiveness of 3f to inhibit JUNV multiplication was not importantly affected by the initial multiplicity of infection, with similar effective concentration 50% (EC(50)) values in virus yield inhibition assays performed in Vero cells in the range of 0.

Antimalarial activity of new acridinone derivatives.

Malaria is one of the major threats concerning world public health. Resistance to the current antimalarial drugs has led to searches for new antimalarial compounds. Acridinone derivatives have recently demonstrated to be active against malaria parasite.

In vitro effect of a new cinnamic acid derivative against the epimastigote form of Trypanosoma cruzi.

An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), and prophylaxis of blood in endemic areas. The preparation and in vitro evaluation as potential anti-protozoal agent of (2E)-N-(1,3-benzothiazol-2-yl)-3-(2,5-dimethoxyphenyl)-2-propenamide (CAD-1) is presented.

1H and 13C spectral assignment of substituted 5H-[1,3]thiazolo[2,3-b]quinazolin-5-one and 12H-[1,3]benzothiazolo[2,3-b] quinazolin-12-one.

(1)H and (13)C spectroscopic data for 5H-[1,3]thiazolo[2,3-b]quinazolin-5-one and 12H-[1,3]benzothiazolo[2,3-b]quinazolin-12-one derivatives were fully assigned by combination of one- and two-dimensional experiments (DEPT, HMBC and HMQC). Both heterocyclic systems show similar spectroscopic properties with some remarkable differences.

Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses.

Background: In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV).

Methods: Compounds were tested against Junin virus (JUNV), an arenavirus agent of Argentine haemorrhagic fever, and dengue virus (DENV), a flavivirus agent of the most prevalent arthropod-borne viral disease in humans.

Results: Among tested compounds, two N-allyl acridones (derivatives 3c and 3f) elicited a potent and selective antiviral activity against JUNV (strain 1V4454) and DENV-2 (strain NGC) with 50% effective concentration values between 2.

Effects of p-vinylphenyl glycosides and other related compounds on the oviposition behavior of Ceratitis capitata.

Elaphoside-A [p-vinylphenyl (beta-D: -glucopyranosyl)-(1-->3)-beta-D: -allopyranoside], a Mediterranean fruit fly oviposition deterrent, was previously isolated from an Argentine collection of the fern Elaphoglossum piloselloides. In order to establish the structural requirements for the observed oviposition inhibition, we synthesized and characterized 4 known and 21 new aromatic glycosides structurally related to elaphoside-A. Their effects on the oviposition behavior of Ceratitis capitata females are discussed.

Synthesis, high-resolution NMR spectroscopic analysis, and single-crystal X-ray diffraction of isoxazoline tetracycles.

Three isoxazoline tetracycles were obtained enantiomerically pure by intramolecular 1,3-dipolar cycloaddition. The characterization of the new compounds was performed by high-resolution 1H and 13C NMR spectroscopy. The relative configuration of the new chiral centers was determined by NOESY experiments and confirmed by single-crystal X-ray structural analysis.